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Nitrate, nitrite, and nitric oxide find a home in the kidney by offsetting angiotensin II-mediated hypertension.

作者信息

Kennedy Chris R J

机构信息

From the Kidney Research Centre, Division of Nephrology, Department of Medicine, Ottawa Hospital Research Institute; and Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario, Canada.

出版信息

Hypertension. 2015 Jan;65(1):31-3. doi: 10.1161/HYPERTENSIONAHA.114.04349. Epub 2014 Oct 13.

DOI:10.1161/HYPERTENSIONAHA.114.04349
PMID:25312438
Abstract
摘要

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Nitrate, nitrite, and nitric oxide find a home in the kidney by offsetting angiotensin II-mediated hypertension.硝酸盐、亚硝酸盐和一氧化氮通过抵消血管紧张素 II 介导的高血压在肾脏中发挥作用。
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NADPH oxidase in the renal microvasculature is a primary target for blood pressure-lowering effects by inorganic nitrate and nitrite.在肾脏微血管中，NADPH 氧化酶是无机硝酸盐和亚硝酸盐降低血压作用的主要靶点。
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Dietary nitrate improves age-related hypertension and metabolic abnormalities in rats via modulation of angiotensin II receptor signaling and inhibition of superoxide generation.膳食硝酸盐通过调节血管紧张素II受体信号传导和抑制超氧化物生成，改善大鼠与年龄相关的高血压和代谢异常。
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Direct comparison of inorganic nitrite and nitrate on vascular dysfunction and oxidative damage in experimental arterial hypertension.无机亚硝酸盐和硝酸盐对实验性动脉高血压血管功能障碍和氧化损伤的直接比较。
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Mechanisms impairing blood pressure responses to nitrite and nitrate.损害硝酸盐和亚硝酸盐引起血压反应的机制。
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Enhanced XOR activity in eNOS-deficient mice: Effects on the nitrate-nitrite-NO pathway and ROS homeostasis.eNOS 缺陷小鼠中增强的异或活性：对硝酸盐-亚硝酸盐-一氧化氮途径和活性氧稳态的影响。
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Dietary nitrate increases gastric mucosal blood flow and mucosal defense.膳食硝酸盐可增加胃黏膜血流量和黏膜防御功能。
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Hypothesis: the effect of oral nitrite on blood pressure in the spontaneously hypertensive rat. Does dietary nitrate mitigate hypertension after conversion to nitrite?假设：口服亚硝酸盐对自发性高血压大鼠血压的影响。转化为亚硝酸盐后，膳食硝酸盐是否能减轻高血压？
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引用本文的文献

1
Association between Dietary Intakes of Nitrate and Nitrite and the Risk of Hypertension and Chronic Kidney Disease: Tehran Lipid and Glucose Study.硝酸盐和亚硝酸盐的膳食摄入量与高血压和慢性肾脏病风险之间的关联：德黑兰脂质与血糖研究
Nutrients. 2016 Dec 21;8(12):811. doi: 10.3390/nu8120811.