Yang Chao, Jin Ming
Beijing University of Chinese Medicine, China-Japan Friendship Hospital, Beijing 100029, China.
Beijing University of Chinese Medicine, China-Japan Friendship Hospital, Beijing 100029, China. Email:
Zhonghua Yan Ke Za Zhi. 2014 Jul;50(7):550-2.
Avian influenza virus (AIV) has caused several outbreaks in humans, leading to disasters to human beings. The outbreak of H7N9 avian influenza in China in 2003 re-attracted our close attention to this disease. More and more evidences demonstrated that eye is one of invasion portals of AIV, leading to conjunctivitis. The current studies showed that only subtypes H7 and H5 could cause severe systemic infections. Abundant distribution of α-2, 3 siliac acid receptor in conjunctiva and cornea as well as specific activiation of NF-κB signal transduction pathway by subtype H7 virus may contribute to the ocular tropism of the virus. These studies suggest that avian influenza conjunctivitis should be considered as a differential diagnosis during influenza epidemic seasons, and eyes should be well protected for disease control personnel when handling avian influenza epidemics. This review focused on AIV conjunctivitis and the molecular basis of ocular tropism.
禽流感病毒（AIV）已在人类中引发了数次疫情，给人类带来了灾难。2003年中国H7N9禽流感疫情的爆发再次引起了我们对这种疾病的密切关注。越来越多的证据表明，眼睛是AIV的入侵门户之一，可导致结膜炎。目前的研究表明，只有H7和H5亚型能够引起严重的全身感染。结膜和角膜中α-2,3唾液酸受体的大量分布以及H7亚型病毒对NF-κB信号转导通路的特异性激活可能导致了该病毒的眼嗜性。这些研究表明，在流感流行季节应将禽流感结膜炎作为鉴别诊断的考虑因素，并且在应对禽流感疫情时，应妥善保护疾病防控人员的眼睛。本综述聚焦于AIV结膜炎及眼嗜性的分子基础。
