全关节置换术与中重度骨关节炎患者严重心血管事件风险的关系：倾向评分匹配标志分析。
The relation between total joint arthroplasty and risk for serious cardiovascular events in patients with moderate-severe osteoarthritis: propensity score matched landmark analysis.
机构信息
Division of Orthopaedic Surgery, Department of Surgery, University of Toronto, Canada Institute of Health Policy, Management and Evaluation, University of Toronto, Canada Women's College Research Institute, Women's College Hospital, Toronto, Canada.
Institute for Clinical Evaluative Sciences, Toronto, Canada.
出版信息
Br J Sports Med. 2014 Nov;48(21):1580. doi: 10.1136/bjsports-2014-f6187rep.
STUDY QUESTION
What are the rates of serious cardiovascular events in those who undergo primary total joint arthroplasty (TJA) compared with those who do not within three years of initial assessment?
SUMMARY ANSWER
Undergoing elective primary TJA within three years of initial assessment was associated with a significant 12.4% absolute reduction in subsequent risk of serious cardiovascular events.
WHAT IS KNOWN AND WHAT THIS PAPER ADDS
Osteoarthritis is associated with increased mortality, particularly secondary to cardiovascular disease, with the risk for mortality proportional to the degree of disability secondary to the arthritis. This study suggests that management of hip or knee osteoarthritis with arthroplasty decreases the risk for subsequent serious cardiovascular events.
研究问题
在初始评估后三年内接受初次全关节置换术（TJA）的患者与未接受 TJA 的患者相比，严重心血管事件的发生率是多少？
总结回答
在初始评估后三年内接受择期初次 TJA 与随后严重心血管事件风险降低 12.4%显著相关。
已知和本文添加内容
骨关节炎与死亡率增加有关，特别是继发于心血管疾病，死亡率与关节炎继发的残疾程度成正比。本研究表明，通过关节置换术治疗髋或膝关节骨关节炎可降低随后发生严重心血管事件的风险。
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