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Targeting the low-hanging fruit of neurodegeneration.针对神经退行性病变中易于解决的问题。
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Nourish the roots while picking the fruit.既要摘果实，又要滋养根。
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本文引用的文献

1
Deaths: leading causes for 2009.死亡：2009年的主要死因。
Natl Vital Stat Rep. 2012 Oct 26;61(7):1-94.
2
Multisource ascertainment of Huntington disease in Canada: prevalence and population at risk.加拿大亨廷顿病的多源确定：患病率和风险人群。
Mov Disord. 2014 Jan;29(1):105-14. doi: 10.1002/mds.25717. Epub 2013 Oct 21.
3
Advances in the genetics of Parkinson disease.帕金森病遗传学研究进展。
Nat Rev Neurol. 2013 Aug;9(8):445-54. doi: 10.1038/nrneurol.2013.132. Epub 2013 Jul 16.
4
I-SPY 2 may change how clinical trials are conducted: researchers aim to accelerate approvals of cancer drugs.I-SPY 2试验可能会改变临床试验的开展方式：研究人员旨在加速癌症药物的审批。
Cancer. 2013 Jun 1;119(11):1925-7. doi: 10.1002/cncr.28172.
5
The epidemiology of frontotemporal dementia.额颞叶痴呆的流行病学。
Int Rev Psychiatry. 2013 Apr;25(2):130-7. doi: 10.3109/09540261.2013.776523.
6
A pan-European study of the C9orf72 repeat associated with FTLD: geographic prevalence, genomic instability, and intermediate repeats.一项关于与额颞叶变性相关的 C9orf72 重复序列的泛欧研究：地理流行率、基因组不稳定性和中间重复序列。
Hum Mutat. 2013 Feb;34(2):363-73. doi: 10.1002/humu.22244. Epub 2013 Jan 4.
7
Advances in understanding the molecular basis of frontotemporal dementia.理解额颞叶痴呆分子基础的进展。
Nat Rev Neurol. 2012 Aug;8(8):423-34. doi: 10.1038/nrneurol.2012.117. Epub 2012 Jun 26.
8
Frequency of the C9orf72 hexanucleotide repeat expansion in patients with amyotrophic lateral sclerosis and frontotemporal dementia: a cross-sectional study.C9orf72 六核苷酸重复扩展在肌萎缩侧索硬化症和额颞叶痴呆患者中的频率：一项横断面研究。
Lancet Neurol. 2012 Apr;11(4):323-30. doi: 10.1016/S1474-4422(12)70043-1. Epub 2012 Mar 9.
9
Drug bests cystic-fibrosis mutation.药物战胜囊性纤维化突变。
Nature. 2012 Feb 7;482(7384):145. doi: 10.1038/482145a.
10
Prevalence of apolipoprotein E4 genotype and homozygotes (APOE e4/4) among patients diagnosed with Alzheimer's disease: a systematic review and meta-analysis.载脂蛋白 E4 基因型和纯合子（APOE e4/4）在阿尔茨海默病患者中的患病率：系统评价和荟萃分析。
Neuroepidemiology. 2012;38(1):1-17. doi: 10.1159/000334607. Epub 2011 Dec 17.

Targeting the low-hanging fruit of neurodegeneration.

作者信息

Mason Amanda R, Ziemann Adam, Finkbeiner Steven

机构信息

From the Gladstone Institute of Neurological Disease (A.R.M., A.Z., S.F.), San Francisco; the Developmental and Stem Cell Biology Graduate Program (A.R.M.) and the Departments of Neurology (A.Z., S.F.) and Physiology (S.F.), University of California San Francisco; and the Taube/Koret Center for Neurodegenerative Disease Research (S.F.), San Francisco, CA. A.Z. is currently affiliated with Lundbeck, Deerfield, IL.

出版信息

Neurology. 2014 Oct 14;83(16):1470-3. doi: 10.1212/WNL.0000000000000894.

DOI:10.1212/WNL.0000000000000894
PMID:25313376
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4206158/
Abstract
摘要