Targeting the low-hanging fruit of neurodegeneration.
作者信息
Mason Amanda R, Ziemann Adam, Finkbeiner Steven
机构信息
From the Gladstone Institute of Neurological Disease (A.R.M., A.Z., S.F.), San Francisco; the Developmental and Stem Cell Biology Graduate Program (A.R.M.) and the Departments of Neurology (A.Z., S.F.) and Physiology (S.F.), University of California San Francisco; and the Taube/Koret Center for Neurodegenerative Disease Research (S.F.), San Francisco, CA. A.Z. is currently affiliated with Lundbeck, Deerfield, IL.
出版信息
Neurology. 2014 Oct 14;83(16):1470-3. doi: 10.1212/WNL.0000000000000894.
Abstract
摘要
相似文献
1
Targeting the low-hanging fruit of neurodegeneration.针对神经退行性病变中易于解决的问题。
Neurology. 2014 Oct 14;83(16):1470-3. doi: 10.1212/WNL.0000000000000894.
2
Nourish the roots while picking the fruit.既要摘果实，又要滋养根。
Neurology. 2014 Oct 14;83(16):1473-5. doi: 10.1212/01.wnl.0000455934.19444.86.
3
Foreword: neurodegenerative diseases: challenges and opportunities.前言：神经退行性疾病：挑战与机遇
Future Med Chem. 2012 Sep;4(13):1647-9. doi: 10.4155/fmc.12.123.
4
Modeling neurodegenerative diseases using stem cells: is it accelerating drug discovery?利用干细胞模拟神经退行性疾病：它是否正在加速药物研发？
Future Med Chem. 2012 Sep;4(13):1651-3. doi: 10.4155/fmc.12.101.
5
Cell death assays for neurodegenerative disease drug discovery.用于神经退行性疾病药物发现的细胞死亡分析。
Expert Opin Drug Discov. 2019 Sep;14(9):901-913. doi: 10.1080/17460441.2019.1623784. Epub 2019 Jun 10.
6
Translational Research and Drug Discovery for Neurodegeneration: Challenges for Latin America.神经退行性疾病的转化研究与药物发现：拉丁美洲面临的挑战
J Alzheimers Dis. 2021;82(s1):S1-S4. doi: 10.3233/JAD-210245.
7
8
The fly as a model for neurodegenerative diseases: is it worth the jump?苍蝇作为神经退行性疾病的模型：值得尝试吗？
Neurodegener Dis. 2006;3(6):338-56. doi: 10.1159/000097303.
9
Gene expression profiling and therapeutic interventions in neurodegenerative diseases: a comprehensive study on potentiality and limits.基因表达谱分析和神经退行性疾病的治疗干预：对潜力和限制的综合研究。
Expert Opin Drug Discov. 2012 Mar;7(3):245-59. doi: 10.1517/17460441.2012.659661. Epub 2012 Feb 13.
10
Novel therapeutic strategies in neural diseases uncover unexpected disease connections: from neurodegeneration and addiction to pain and depression.神经疾病的新型治疗策略揭示了意想不到的疾病关联：从神经退行性病变、成瘾到疼痛和抑郁。
Curr Pharm Des. 2011;17(5):408-9. doi: 10.2174/138161211795164121.
引用本文的文献
1
Advances in the Diagnosis and Management of Psychotic Symptoms in Neurodegenerative Diseases: A Narrative Review.神经退行性疾病中精神病症状的诊断和管理进展：叙事性综述。
J Geriatr Psychiatry Neurol. 2023 Nov;36(6):435-460. doi: 10.1177/08919887231164357. Epub 2023 Mar 20.
2
miR-124: A Promising Therapeutic Target for Central Nervous System Injuries and Diseases.miR-124：中枢神经系统损伤和疾病的有前途的治疗靶点。
Cell Mol Neurobiol. 2022 Oct;42(7):2031-2053. doi: 10.1007/s10571-021-01091-6. Epub 2021 Apr 22.
3
Networks Are Associated With Depression in Patients With Parkinson's Disease: A Resting-State Imaging Study.网络与帕金森病患者的抑郁相关：一项静息态成像研究。
Front Neurosci. 2021 Feb 9;14:573538. doi: 10.3389/fnins.2020.573538. eCollection 2020.
4
Prospects of Directly Reprogrammed Adult Human Neurons for Neurodegenerative Disease Modeling and Drug Discovery: iN vs. iPSCs Models.直接重编程的成人人类神经元用于神经退行性疾病建模和药物发现的前景：诱导神经元（iN）与诱导多能干细胞（iPSC）模型
Front Neurosci. 2020 Nov 19;14:546484. doi: 10.3389/fnins.2020.546484. eCollection 2020.
5
Clinical drug development for dementia with Lewy bodies: past and present.路易体痴呆症的临床药物研发：过去与现在。
Expert Opin Investig Drugs. 2019 Nov;28(11):951-965. doi: 10.1080/13543784.2019.1681398. Epub 2019 Oct 28.
6
Han Chinese family with early-onset Parkinson's disease carries novel compound heterozygous mutations in the PARK2 gene.一个有早发性帕金森病的汉族家庭携带 PARK2 基因的新型复合杂合突变。
Brain Behav. 2019 Sep;9(9):e01372. doi: 10.1002/brb3.1372. Epub 2019 Aug 6.
7
Investigation of Nonmotor Symptoms in First-Degree Relatives of Patients with Different Clinical Types of Parkinson's Disease.不同临床类型帕金森病患者一级亲属的非运动症状调查
Parkinsons Dis. 2019 Jan 2;2019:1654161. doi: 10.1155/2019/1654161. eCollection 2019.
8
Pharmacological Management of Dementia with Lewy Bodies.路易体痴呆的药物治疗
Drugs Aging. 2019 Apr;36(4):309-319. doi: 10.1007/s40266-018-00636-7.
9
Repeat-associated non-AUG translation from antisense CCG repeats in fragile X tremor/ataxia syndrome.脆性X震颤/共济失调综合征中反义CCG重复序列的重复相关非AUG翻译。
Ann Neurol. 2016 Dec;80(6):871-881. doi: 10.1002/ana.24800. Epub 2016 Nov 26.
10
RAN translation-What makes it run?RAN翻译——是什么让它运行？
Brain Res. 2016 Sep 15;1647:30-42. doi: 10.1016/j.brainres.2016.04.003. Epub 2016 Apr 6.
本文引用的文献
1
Deaths: leading causes for 2009.死亡：2009年的主要死因。
Natl Vital Stat Rep. 2012 Oct 26;61(7):1-94.
2
Multisource ascertainment of Huntington disease in Canada: prevalence and population at risk.加拿大亨廷顿病的多源确定：患病率和风险人群。
Mov Disord. 2014 Jan;29(1):105-14. doi: 10.1002/mds.25717. Epub 2013 Oct 21.
3
Advances in the genetics of Parkinson disease.帕金森病遗传学研究进展。
Nat Rev Neurol. 2013 Aug;9(8):445-54. doi: 10.1038/nrneurol.2013.132. Epub 2013 Jul 16.
4
I-SPY 2 may change how clinical trials are conducted: researchers aim to accelerate approvals of cancer drugs.I-SPY 2试验可能会改变临床试验的开展方式：研究人员旨在加速癌症药物的审批。
Cancer. 2013 Jun 1;119(11):1925-7. doi: 10.1002/cncr.28172.
5
The epidemiology of frontotemporal dementia.额颞叶痴呆的流行病学。
Int Rev Psychiatry. 2013 Apr;25(2):130-7. doi: 10.3109/09540261.2013.776523.
6
A pan-European study of the C9orf72 repeat associated with FTLD: geographic prevalence, genomic instability, and intermediate repeats.一项关于与额颞叶变性相关的 C9orf72 重复序列的泛欧研究：地理流行率、基因组不稳定性和中间重复序列。
Hum Mutat. 2013 Feb;34(2):363-73. doi: 10.1002/humu.22244. Epub 2013 Jan 4.
7
Advances in understanding the molecular basis of frontotemporal dementia.理解额颞叶痴呆分子基础的进展。
Nat Rev Neurol. 2012 Aug;8(8):423-34. doi: 10.1038/nrneurol.2012.117. Epub 2012 Jun 26.
8
Frequency of the C9orf72 hexanucleotide repeat expansion in patients with amyotrophic lateral sclerosis and frontotemporal dementia: a cross-sectional study.C9orf72 六核苷酸重复扩展在肌萎缩侧索硬化症和额颞叶痴呆患者中的频率：一项横断面研究。
Lancet Neurol. 2012 Apr;11(4):323-30. doi: 10.1016/S1474-4422(12)70043-1. Epub 2012 Mar 9.
9
Drug bests cystic-fibrosis mutation.药物战胜囊性纤维化突变。
Nature. 2012 Feb 7;482(7384):145. doi: 10.1038/482145a.
10
Prevalence of apolipoprotein E4 genotype and homozygotes (APOE e4/4) among patients diagnosed with Alzheimer's disease: a systematic review and meta-analysis.载脂蛋白 E4 基因型和纯合子（APOE e4/4）在阿尔茨海默病患者中的患病率：系统评价和荟萃分析。
Neuroepidemiology. 2012;38(1):1-17. doi: 10.1159/000334607. Epub 2011 Dec 17.
Zotero 插件