Shah Parag K, Bachu Sandeep, Narendran Venkatapathy, Kalpana Narendran, David Jeevamala, Srinivas Chakravarthi R
J Pediatr Ophthalmol Strabismus. 2013 Oct 29;50 Online:e52-4. doi: 10.3928/01913913-20131022-01.
Two eyes of two siblings affected with incontinentia pigmenti having severe proliferative retinopathy are reported. Both cases showed complete resolution of new vessels after a single injection of intravitreal bevacizumab. At 7 months of follow-up, the first case revealed vascularization to the mid-periphery including a vascularized fovea (which was avascular before injection) but recurrence of some peripheral neovascularization, which was treated by conventional laser. The second case had no recurrence. No ocular or systemic adverse effects were observed. Intravitreal bevacizumab as an adjunct therapy in incontinentia pigmenti with macular ischemia could be beneficial.
报告了两例患有色素失禁症并伴有严重增殖性视网膜病变的兄弟姐妹的眼睛。两例患者在单次玻璃体内注射贝伐单抗后，新生血管均完全消退。在7个月的随访中，第一例患者的血管化延伸至中周边部，包括一个血管化的黄斑中心凹（注射前为无血管区），但一些周边新生血管复发，采用传统激光治疗。第二例患者未复发。未观察到眼部或全身不良反应。玻璃体内注射贝伐单抗作为色素失禁症合并黄斑缺血的辅助治疗可能有益。
