Salcedo-Villanueva Guillermo, Harasawa Mariana, Velez-Montoya Raul, Mathias Marc T, Siringo Frank S, Olson Jeffrey L, Oliver Scott C, Mandava Naresh, Quiroz-Mercado Hugo
*Department of Ophthalmology, University of Colorado School of Medicine, Denver Health Medical Center, Denver, Colorado; and †Rocky Mountains Lions Eye Institute, University of Colorado School of Medicine, Aurora, Colorado.
Retina. 2015 Apr;35(4):704-14. doi: 10.1097/IAE.0000000000000373.
To propose a model that measures the effect of intravitreal bevacizumab (IVB) on relatively healthy retina. The purpose is to analyze the remote effect of a branch retinal vein occlusion in the healthy retina, to determine the response it may have to IVB, and to determine if IVB has an atrophic effect on the healthy retina.
Retrospective, longitudinal comparative analysis of patients with branch retinal vein occlusion treated with IVB. Eyes were divided into experimental (branch retinal vein occlusion eye) and control (contralateral eye) groups. Each eye was analyzed for thickness and area. Thickness measurements were performed for total retinal thickness, inner retina thickness, and outer retina thickness. Area was measured for photoreceptors, choroid, and total retina.
Eighteen eyes of 9 patients. For thickness analysis, 1,050 scans were studied, and 126 measurements were performed on 42 scans for area analysis. No difference was observed for thickness, except for inner retina thickness. No difference was observed for area. No difference was observed when analyzing a cumulative exposure to IVB.
There is no evidence to suggest an atrophic effect caused by IVB when analyzing thickness or area in this experiment. This model could be used to analyze the long-term safety of IVB in larger studies.
提出一种测量玻璃体内注射贝伐单抗（IVB）对相对健康视网膜影响的模型。目的是分析视网膜分支静脉阻塞在健康视网膜中的远程效应，确定其对IVB可能产生的反应，并确定IVB是否对健康视网膜有萎缩作用。
对接受IVB治疗的视网膜分支静脉阻塞患者进行回顾性纵向对比分析。将眼睛分为实验组（视网膜分支静脉阻塞眼）和对照组（对侧眼）。对每只眼睛的厚度和面积进行分析。测量总视网膜厚度、视网膜内层厚度和视网膜外层厚度。测量光感受器、脉络膜和整个视网膜的面积。
9例患者的18只眼睛。对于厚度分析，研究了1050次扫描，对42次扫描进行了126次面积分析测量。除视网膜内层厚度外，未观察到厚度差异。未观察到面积差异。分析IVB的累积暴露量时未观察到差异。
在本实验中分析厚度或面积时，没有证据表明IVB会产生萎缩作用。该模型可用于在更大规模研究中分析IVB的长期安全性。
