Na Seong Woong, Yu Seong Hyeon, Kim Kwang Ho, Hwang Eu Chang, Jung Seung Il, Kwon Dong Deuk, Kang Taek Won
Department of Urology, Research Institute of Medical Sciences, Chonnam National University Medical School, Gwangju, Korea.
J Cancer Res Ther. 2014 Jul-Sep;10(3):710-4. doi: 10.4103/0973-1482.137928.
Natural history of young patients with bladder cancer has not yet been known. So this study aimed to understand characteristics and prognosis of patients less than 40 years with bladder cancer.
We retrospectively analyzed 42 patients (group 1) less than 40 years with bladder cancer followed up for 6 months at least from October 1998 to January 2010. As controlled group (group 2) consisted 44 patients of 60 years or more who had same condition as above mentioned from January to December 2009 was set. Tumor size and number, pathological results, urine cytology results and recurrence rate were reviewed.
The mean ages and the gender distribution in the two groups showed no difference. Tumor size (P = 0.021) and number (P = 0.016) in group 1 was smaller than control. The proportion of muscle invasive type was not significant, but pTa in group 1 was occupied larger portion than group 2 (P = 0.01). Group 1 had more low grade cancer (P = 0.013), and lower recurrence rate (7.1%) than group 2 (38.6%) (P = 0.001). In addition, the mean recurrence free duration of group 1 and 2 were 37.7 ± 6.3 and 9.9 ± 2.5 months, respectively. Group 1 showed later relapse than group 2 (P = 0.002). No progression in stage at recurrence was in group 1, but 1 case had progression in group 2. In grade, 1 case was worsen in group 1 and 3 cases were worsen in group 2.
膀胱癌年轻患者的自然病史尚不明确。因此，本研究旨在了解年龄小于40岁的膀胱癌患者的特征及预后情况。
我们回顾性分析了1998年10月至2010年1月期间42例年龄小于40岁的膀胱癌患者（第1组），这些患者至少随访了6个月。设立对照组（第2组），由2009年1月至12月期间44例年龄60岁及以上且病情与上述相同的患者组成。对肿瘤大小、数量、病理结果、尿液细胞学结果及复发率进行了评估。
两组患者的平均年龄和性别分布无差异。第1组的肿瘤大小（P = 0.021）和数量（P = 0.016）均小于对照组。肌层浸润型的比例无显著差异，但第1组中pTa所占比例高于第2组（P = 0.01）。第1组低级别癌症更多（P = 0.013），且复发率（7.1%）低于第2组（38.6%）（P = 0.001）。此外，第1组和第2组的平均无复发生存时间分别为37.7±6.3个月和9.9±2.5个月。第1组的复发时间晚于第2组（P = 0.002）。第1组复发时无分期进展，但第2组有1例分期进展。在分级方面，第1组有1例病情恶化，第2组有3例病情恶化。
