Pornet C, Denis B, Perrin P, Gendre I, Launoy G
8216;Cancers & Preventions' INSERM U 1086, University of Caen Basse-Normandie, CHU, Caen France.
Association pour le dépistage du cancer colorectal en Alsace, 122 rue Logelbach, Colmar, France.
Br J Cancer. 2014 Nov 25;111(11):2152-5. doi: 10.1038/bjc.2014.507. Epub 2014 Oct 14.
Socio-economic, environmental factors and general practitioner (GP) involvement may influence adherence to repeat faecal occult blood testing (FOBT) of organised colorectal cancer (CRC) screening. The aim of the study was to identify predictors of adherence to repeat testing.
The populationcomprised people eligible for the third round of a CRC screening programme in a French district (n=118,905). Multilevel logistic regression analysis was performed to identify individual and area-level characteristics associated with 'compliant participants' participating in the all three rounds vs 'occasional participants' participating in one or two rounds.
Compared to 'occasional participants', 'compliant participants' were more likely to participate after receiving a FOBT kit from their GP (odds ratio (OR), 10.7; 95% CI, 10.01-11.5) vs FOBT received at home, and were less likely to live in socio-economically deprived areas (OR, 0.75; 0.70-0.80) and urban areas (OR, 0.94; 0.88-1.00).
As for a screening round participation, strategies aimed at improving the participation to a screening programme should target GPs and people living in socially deprived areas.
社会经济、环境因素以及全科医生（GP）的参与可能会影响有组织的结直肠癌（CRC）筛查中重复粪便潜血试验（FOBT）的依从性。本研究的目的是确定重复检测依从性的预测因素。
研究人群包括法国某地区符合第三轮CRC筛查计划条件的人（n = 118,905）。进行多水平逻辑回归分析，以确定与参加了所有三轮筛查的“依从参与者”和参加了一轮或两轮筛查的“偶尔参与者”相关的个体和地区层面特征。
与“偶尔参与者”相比，“依从参与者”在从全科医生处收到FOBT检测试剂盒后参加筛查的可能性更大（优势比（OR）为10.7；95%置信区间为10.01 - 11.5），而不是在家中收到FOBT检测试剂盒后；并且生活在社会经济贫困地区（OR为0.75；0.70 - 0.80）和城市地区（OR为0.94；0.88 - 1.00）的可能性较小。
对于一轮筛查的参与情况而言，旨在提高筛查计划参与度的策略应针对全科医生以及生活在社会贫困地区的人群。
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