通过 GADD45 和 MKK7 对 NF-κB 的鞭打
Whipping NF-κB to Submission via GADD45 and MKK7.
机构信息
Laboratory of Gene Regulation and Signal Transduction, Departments of Pharmacology and Pathology, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA; Moores Cancer Center, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA.
出版信息
Cancer Cell. 2014 Oct 13;26(4):447-9. doi: 10.1016/j.ccell.2014.09.012.
NF-κB protects malignant cells from death and therefore it was considered as a cancer treatment target. However, systemic NF-κB inhibition resulted in inflammation and other undesired outcomes. In this issue of Cancer Cell, Tornatore and colleagues solve this problem by targeting the GADD45:MKK7 module mediating NF-κB-induced survival of multiple myelomas.
NF-κB 可保护恶性细胞免于死亡，因此被视为癌症治疗的靶点。然而，全身性 NF-κB 抑制会导致炎症和其他不良后果。在本期《癌细胞》杂志中，Tornatore 及其同事通过靶向介导 NF-κB 诱导多发性骨髓瘤细胞存活的 GADD45:MKK7 模块解决了这个问题。
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