Belz G G, Beermann C, Schloos J, Kleinbloesem C H
Centre for Cardiovascular Pharmacology Ltd, Wiesbaden, F.R.G.
Br J Clin Pharmacol. 1989 Nov;28(5):608-11. doi: 10.1111/j.1365-2125.1989.tb03550.x.
The effects of the ACE inhibitor cilazapril (5 mg p.o.) and the alpha 1-adrenoceptor blocker prazosin (2 mg p.o.) were investigated on the dose-response curves to angiotensin I and to noradrenaline, administered locally in the hand veins in six healthy male volunteers in doses not producing systemic effects. Both angiotensin I and noradrenaline produced a dose-dependent constriction of the congested veins. The angiotensin I effects were completely abolished after the administration of cilazapril but not significantly altered after the administration of prazosin. The noradrenaline dose-response curves were shifted to the right (dose ratio about 10) by prazosin, but not by cilazapril. The data suggest that angiotensin I, after having been converted to angiotensin II exerts direct venoconstrictor effects which under resting conditions are not mediated by noradrenaline release.
在6名健康男性志愿者的手部静脉局部给予不会产生全身效应的剂量，研究了血管紧张素转换酶（ACE）抑制剂西拉普利（口服5毫克）和α1肾上腺素能受体阻滞剂哌唑嗪（口服2毫克）对血管紧张素I和去甲肾上腺素剂量-反应曲线的影响。血管紧张素I和去甲肾上腺素均可使充血静脉产生剂量依赖性收缩。给予西拉普利后，血管紧张素I的效应完全消除，但给予哌唑嗪后未发生显著改变。哌唑嗪使去甲肾上腺素的剂量-反应曲线右移（剂量比约为10），而西拉普利则无此作用。数据表明，血管紧张素I转化为血管紧张素II后发挥直接的静脉收缩作用，在静息状态下这种作用并非由去甲肾上腺素释放介导。
