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葡萄糖耐量:对马来西亚糖尿病群体的假设检验

Glucose tolerance: hypothesis testing on Malaysian diabetic community.

作者信息

Gillani Syed Wasif, Sari Yelly Oktavia, Sulaiman Syed Azhar Syed, Baig Mirza R

机构信息

School of Pharmacy, Monash University Malaysia, PO box 46150, Bandar Sunway, Selangor, Malaysia.

出版信息

Curr Diabetes Rev. 2014;10(5):311-26. doi: 10.2174/1573399810666141015095004.

Abstract

Our study objective was to evaluate glucose tolerance and effecting factors among diabetes patients' with home care program (PHCP) in Malaysian community. A 24-week longitudinal quasi-experimental -single blind - pre/post-test study design was used to assess the effectiveness of a diabetes education program to enhance self-care practices. An attrition rate of 25% implied longitudinal design of the study in the calculation of sample size. Hence the sample size of the study was 106 subjects (53 cases and 53 focus group). The level of significance was set at 0.05. Ethical clearance had been made prior to conducting this study. Of the 109 subjects who met the study-entry criteria, 3 subjects declined to participate due to lack of time and interest. No significant parameters were revealed in the demographic and clinical characteristics of participants who completed the study. Focus group showed significant reduction in HbA1c value with mean 1.1% as compared to cases with a mean 0.06%. Similarly, hypothesis on self-care management suggest significantly improved practices among focus group [M=2.94, SD=2.25] for case group M=0.47, SD=1.36; t[127.64]=-8.23, p≤0.001] with moderate effect size [eta squared=0.06]. Total physical activity was defined as the combination of non-leisure and leisure activities. There was a statistically significant difference for increase in total physical levels between the focus [M=14.01, SD=6.41] and case groups [13.21, SD=5.22; t[148.04]=-3.15, p=0.002] with no difference in the non-leisure activity [p=0.43]. As for the case group, there was no significant difference in SMBG practices from baseline [M=0.70, SD=1.35] to follow-up [M=0.47, SD=1.36, t[72]=0.97, P=0.34] and no relationship was found between the number of blood glucose tests done with demographic or clinical variables. This study offered improved self-care practices and physical activity after PHCP but with problematic dietary care. This might be due to social and cultural habits among Malaysian population.

摘要

我们的研究目的是评估马来西亚社区中接受家庭护理计划(PHCP)的糖尿病患者的葡萄糖耐量及其影响因素。采用为期24周的纵向准实验——单盲——前后测试研究设计,以评估糖尿病教育计划增强自我护理行为的有效性。在计算样本量时,25%的损耗率意味着该研究采用纵向设计。因此,该研究的样本量为106名受试者(53例和53个焦点组)。显著性水平设定为0.05。在开展本研究之前已获得伦理批准。在符合研究入选标准的109名受试者中,3名受试者因缺乏时间和兴趣而拒绝参与。完成研究的参与者的人口统计学和临床特征未显示出显著参数。与病例组平均降低0.06%相比,焦点组的糖化血红蛋白(HbA1c)值显著降低,平均降低1.1%。同样,关于自我护理管理的假设表明,焦点组[M = 2.94,标准差 = 2.25]的自我护理行为有显著改善,而病例组为[M = 0.47,标准差 = 1.36;t[127.64] = -8.23,p≤0.001],效应量中等[偏 eta 方 = 0.06]。总身体活动被定义为非休闲活动和休闲活动的总和。焦点组[M = 14.01,标准差 = 6.41]和病例组[M = 13.21,标准差 = 5.22;t[148.04] = -3.15,p = 0.002]之间的总身体活动水平增加存在统计学显著差异,而非休闲活动无差异[p = 0.43]。对于病例组,自我血糖监测(SMBG)行为从基线[M = 0.70,标准差 = 1.35]到随访[M = 0.47,标准差 = 1.36,t[72] = 0.97,P = 0.34]无显著差异,且进行的血糖测试次数与人口统计学或临床变量之间未发现相关性。本研究表明,家庭护理计划后自我护理行为和身体活动有所改善,但饮食护理存在问题。这可能是由于马来西亚人群的社会和文化习惯所致。

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