Tøttenborg Sandra Søgaard, Topp Marie, Ingebrigtsen Truls Sylvan, Lange Peter
Afdeling for Social Medicin, Institut for Folkesundhedsvidenskab, Københavns Universitet. Øster Farimagsgade 5, 1014 København K.
Ugeskr Laeger. 2014 Oct 13;176(42).
Non-adherence to medicine is common in patients with chronic diseases, contributing to significant worsening of disease, increased mortality and health expenditure. Methods of measuring adherence include self report, prescription refill rates, biomarkers, electronic monitoring and therapeutic outcomes. Yet, no "gold standard" for assessing adherence and no consensus on what is an acceptable level exist. Physicians should be aware of non-adherence and, although it may not always be identical with the evidence-based regimen, they can facilitate good adherence by simplifying regimens and adapting treatments to the patient's lifestyle and preferences.
慢性病患者不遵医嘱服药的情况很常见,这会导致病情显著恶化、死亡率增加和医疗费用上升。衡量依从性的方法包括自我报告、处方 refill 率、生物标志物、电子监测和治疗结果。然而,目前尚无评估依从性的“金标准”,对于什么是可接受的水平也没有达成共识。医生应该意识到不遵医嘱服药的问题,尽管这可能并不总是与循证治疗方案一致,但他们可以通过简化治疗方案并使治疗适应患者的生活方式和偏好来促进良好的依从性。 注:这里原文中的“prescription refill rates”不太明确准确意思,直译为“处方 refill 率”,你可根据实际情况进一步确认准确译法。