Syed Muhammad A, Bana Noureen F
Department of Microbiology, University of Haripur, Hattar Road, Haripur 22620, Pakistan. Tel. +92 995615394. E-mail.
Saudi Med J. 2014 Oct;35(10):1181-7.
Pertussis or whooping cough is a highly infectious, vaccine preventable disease. The incidence of the disease has greatly been reduced since the introduction of the diphtheria, tetanus, pertussis vaccine. Pertussis resurgence has been observed in highly vaccinated populations of Western countries since 1990s. Poor vaccine quality, waning vaccine induced immunity, pathogen adaptation, and enhanced surveillance as well as advancements in diagnostic facilities are some of the reasons considered responsible for the increased reporting of pertussis cases. Pertussis may have been ignored and unnoticed due to its atypical manifestations in partially immunized population or people with waning immunity. We review the reports of pertussis resurgence from different countries and attempt to investigate reasons behind the reappearance of the disease. Pertussis is still an under reported disease and the available data from the developing countries is not a true picture of the story. Therefore, developing countries need to improve their surveillance systems.
百日咳是一种传染性很强、可用疫苗预防的疾病。自从引入白喉、破伤风、百日咳疫苗以来，该疾病的发病率已大幅降低。自20世纪90年代以来，在西方国家疫苗接种率很高的人群中观察到了百日咳的卷土重来。疫苗质量差、疫苗诱导的免疫力减弱、病原体适应性变化、监测加强以及诊断设施的进步是被认为导致百日咳病例报告增加的一些原因。由于百日咳在部分免疫人群或免疫力减弱的人群中表现不典型，可能被忽视且未被注意到。我们回顾了来自不同国家的百日咳卷土重来的报告，并试图调查该疾病再次出现的背后原因。百日咳仍然是一种报告不足的疾病，发展中国家的现有数据并不能真实反映情况。因此，发展中国家需要改进其监测系统。
