Sethi Sean K, Utriainen David T, Daugherty Ana M, Feng Wei, Hewett J Joseph, Raz Naftali, Haacke E Mark
MRI Institute of Biomedical Research, Detroit, Michigan.
Institute of Gerontology and Department of Psychology, Wayne State University, Detroit, Michigan.
J Neuroimaging. 2015 Jul-Aug;25(4):600-7. doi: 10.1111/jon.12183. Epub 2014 Oct 15.
To determine if extracranial venous structural and flow abnormalities exist in patients with multiple sclerosis (MS).
Magnetic resonance imaging was used to assess the anatomy and function of major veins in the neck in 138 MS patients and 67 healthy controls (HC). Time-of-flight MR angiography (MRA) was used to assess stenosis while 2-dimensional phase-contrast flow quantification was used to assess flow at the C2/C3 and C5/C6 levels. Venous flow was normalized to the total arterial flow. The MS patients were divided into stenotic (ST) and nonstenotic (NST) groups based on MRA assessment, and each group was compared to the HC group in anatomy and flow.
The MS group showed lower normalized internal jugular vein (IJV) blood flow (tIJV/tA) than the HC group (P < .001). In the MS group, 72 (52%) were classified as ST while 66 (48%) were NST. In the HC group, 11 (23%) were ST while 37 (77%) were NST. The ST-MS group had lower IJV flow than both HC and NST-MS groups.
After categorizing the MS population into two groups based upon anatomical stenosis, as determined from an absolute quantification of IJV cross section, clear differences in IJV flow between the ST-MS and HC samples became evident. Despite the unknown etiology of MS, abnormal venous flow was noted in a distinct group of MS patients compared to HC.
确定多发性硬化症（MS）患者是否存在颅外静脉结构和血流异常。
采用磁共振成像评估138例MS患者和67例健康对照者（HC）颈部主要静脉的解剖结构和功能。采用时间飞跃磁共振血管造影（MRA）评估狭窄情况，同时采用二维相位对比血流定量法评估C2/C3和C5/C6水平的血流。静脉血流以总动脉血流进行标准化。根据MRA评估将MS患者分为狭窄组（ST）和非狭窄组（NST），并将每组与HC组在解剖结构和血流方面进行比较。
MS组的标准化颈内静脉（IJV）血流（tIJV/tA）低于HC组（P <.001）。在MS组中，72例（52%）被归类为ST，66例（48%）为NST。在HC组中，11例（23%）为ST，37例（77%）为NST。ST-MS组的IJV血流低于HC组和NST-MS组。
根据IJV横截面的绝对定量确定的解剖狭窄情况将MS人群分为两组后，ST-MS组和HC组样本之间IJV血流的明显差异变得明显。尽管MS的病因不明，但与HC相比，在一组特定的MS患者中发现了异常静脉血流。
