印度西部一家三级医疗中心多次输血患者的红细胞同种免疫。
Red blood cell alloimmunization in multitransfused patients in a tertiary care center in Western India.
作者信息
Philip Joseph, Biswas Amit Kumar, Hiregoudar Sumathi, Kushwaha Neerja
机构信息
Department of Immunohematology and Blood Transfusion, Armed Forces Medical College, Pune, Maharashtra, India
Department of Immunohematology and Blood Transfusion, Armed Forces Medical College, Pune, Maharashtra, India.
出版信息
Lab Med. 2014 Fall;45(4):324-30. doi: 10.1309/LMUCV97YUWQKAHU4.
OBJECTIVE
To investigate the seroprevalence and specificity of red blood cell (RBC) antibodies in multitransfused patients, in whom the risk of alloimmunization is especially high.
METHODS
We conducted a retrospective study on blood specimens from 200 multitransfused patients. We evaluated all specimens for alloimmunization using various immunohematological tests via the column agglutination technique.
RESULTS
The overall prevalence of RBC alloantibodies was 5.5%. Of the 11 specific types of alloantibodies identified, most (72.7%) belonged to the Rh blood group system, followed by the S, M, and Lewis blood group systems (9.1% each).
CONCLUSION
Most alloantibodies were of the Rh blood group specificity. To improve the quality of blood supplied, especially to patients with thalassemia, we recommend that Rh phenotyped, cross-match-compatible blood should be issued to prevent complications such as acute and delayed hemolytic reactions.
目的
调查多次输血患者中红细胞（RBC）抗体的血清流行率及特异性，这类患者发生同种免疫的风险特别高。
方法
我们对200例多次输血患者的血标本进行了一项回顾性研究。我们通过柱凝集技术，使用各种免疫血液学检测方法评估所有标本的同种免疫情况。
结果
RBC同种抗体的总体流行率为5.5%。在鉴定出的11种特异性同种抗体类型中，大多数（72.7%）属于Rh血型系统，其次是S、M和Lewis血型系统（各占9.1%）。
结论
大多数同种抗体具有Rh血型特异性。为提高供血质量，尤其是对地中海贫血患者的供血质量，我们建议发放Rh表型匹配且交叉配血相容的血液，以预防急性和迟发性溶血反应等并发症。
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