Properzi G, Francavilla S, Vicentini C, Cordeschi G, Galassi P, Paradiso Galatioto G, Miano L
Department of Internal Medicine (Andrology), University of L'Aquila, Italy.
Eur Urol. 1989;16(6):426-32.
Twelve patients (age range: 53-78 years) with prostatic cancer were treated with Buserelin (1.2 mg/day) and cyproterone acetate (150 mg/day). Testicular biopsies performed after 13-96 weeks of treatment were compared to those obtained from 6 untreated men of similar age. Deranged spermatogenesis was observed in all but 1 treated patient. The appearance of immature Sertoli cells and atrophic Leydig cells suggests a condition of pharmacologic 'hypophysectomy'. The variable damage to the seminiferous epithelium and findings of an incomplete involution of Leydig cells suggested a decreased but still present testicular steroidogenesis.
12名前列腺癌患者（年龄范围：53 - 78岁）接受了布舍瑞林（1.2毫克/天）和醋酸环丙孕酮（150毫克/天）治疗。将治疗13 - 96周后进行的睾丸活检结果与6名年龄相仿的未治疗男性的睾丸活检结果进行了比较。除1名接受治疗的患者外，其他所有患者均观察到生精紊乱。未成熟支持细胞和萎缩性间质细胞的出现提示存在药物性“垂体切除术”状态。生精上皮的不同程度损伤以及间质细胞不完全退化的表现提示睾丸类固醇生成减少但仍存在。
