Eye Institute of Shandong Traditional Chinese Medicine University, Affiliated Eye Hospital of Shandong University of Traditional Chinese Medicine, Ophthalmology Department of Second Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan 250001, Shandong Province, China.
Neural Regen Res. 2012 Dec 15;7(35):2778-83. doi: 10.3969/j.issn.1673-5374.2012.35.005.
In this study, 16 patients (19 eyes) with nonarteritic anterior ischemic optic neuropathy in the acute stage (within 4 weeks) and resolving stage (after 12 weeks) were diagnosed by a series of complete ophthalmic examinations, including fundus examination, optical coherence tomography and fluorescein fundus angiography, and visual field defects were measured with standard automated perimetry. The contralateral uninvolved eyes were used as controls. The retinal nerve fiber layer thickness was determined by optical coherence tomography which showed that the mean retinal nerve fiber layer thickness and the retinal nerve fiber layer thickness from temporal, superior, nasal and inferior quadrants were significantly higher for all measurements in the acute stage than the corresponding normal values. In comparison, the retinal nerve fiber layer thickness from each optic disc quadrant was found to be significantly lower when measured at the resolving stages, than in the control group. Statistical analysis on the correlation between optic disc nerve fiber layer thickness and visual defects demonstrated a positive correlation in the acute stage and a negative correlation in the resolving stage. Our experimental findings indicate that optical coherence tomography is a useful diagnostic method for nonarteritic anterior ischemic optic neuropathy and can be used to evaluate the effect of treatment.
在这项研究中，通过一系列完整的眼科检查，包括眼底检查、光学相干断层扫描和荧光素眼底血管造影，对 16 例（19 只眼）处于急性阶段（4 周内）和缓解阶段（12 周后）的非动脉炎性前部缺血性视神经病变患者进行了诊断，并用标准自动视野计测量了视野缺损。将对侧未受累的眼睛作为对照。光学相干断层扫描显示，视网膜神经纤维层厚度在急性阶段的所有测量中，平均视网膜神经纤维层厚度和颞、上、鼻和下象限的视网膜神经纤维层厚度均明显高于相应的正常值。相比之下，在缓解阶段测量时，每个视盘象限的视网膜神经纤维层厚度均明显低于对照组。对视盘神经纤维层厚度与视觉缺陷之间相关性的统计分析表明，在急性阶段呈正相关，在缓解阶段呈负相关。我们的实验结果表明，光学相干断层扫描是一种有用的非动脉炎性前部缺血性视神经病变的诊断方法，可用于评估治疗效果。
