人参皂苷 Rg1 防治阿尔茨海默病的细胞和分子机制。
Cellular and molecular mechanisms underlying the action of ginsenoside Rg1 against Alzheimer's disease.
机构信息
Department of Geriatrics, Second Affiliated Hospital, College of Medicine, Xi'an Jiaotong University, Xi'an 710004, Shaanxi Province, China.
Department of Encephalopathy, Xi'an Electric Power Central Hospital, Xi'an 710032, Shaanxi Province, China.
出版信息
Neural Regen Res. 2012 Dec 25;7(36):2860-6. doi: 10.3969/j.issn.1673-5374.2012.36.002.
Ginsenoside Rg1 inhibits oxidation, aging and cell apoptosis, and improves cognitive function. In this study, we pretreated rat brain tissue sections with ginsenoside Rg1, and established brain slice models of Alzheimer's disease induced by okadaic acid. The results revealed that ginsenoside Rg1 pretreatment suppressed the increase in phosphorylated Tau protein expression induced by incubation with okadaic acid, and reduced brain-derived neurotrophic factor expression. These results suggest that ginsenoside Rg1 upregulates brain-derived neurotrophic factor expression and inhibits Tau protein phosphorylation in brain slices from a rat model of Alzheimer's disease.
人参皂苷 Rg1 可抑制氧化、衰老和细胞凋亡，改善认知功能。在本研究中，我们用人参皂苷 Rg1 预处理大鼠脑组织切片，并建立了冈田酸诱导的阿尔茨海默病脑片模型。结果表明，人参皂苷 Rg1 预处理抑制了冈田酸孵育引起的磷酸化 Tau 蛋白表达的增加，并降低了脑源性神经营养因子的表达。这些结果提示，人参皂苷 Rg1 可上调阿尔茨海默病大鼠脑片中脑源性神经营养因子的表达，并抑制 Tau 蛋白磷酸化。
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