Department of Nuclear Medicine, Affiliated Hospital of Inner Mongolia Medical College, Hohhot 010050, Inner Mongolia Autonomous Region, China.
Department of Gamma Knife Center, Affiliated Hospital of Inner Mongolia Medical College, Hohhot 010050, Inner Mongolia Autonomous Region, China.
Neural Regen Res. 2012 Dec 25;7(36):2937-43. doi: 10.3969/j.issn.1673-5374.2012.36.012.
A total of 80 patients with refractory epilepsy were recruited from the Inner Mongolia Medical College Affiliated Hospital. The foci of 60% of the patients could be positioned using a combined positron emission tomography/CT imaging modality. Hyper- and hypometabolism foci were examined as part of this study. Patients who had abnormal metabolism in positron emission tomography/CT imaging were divided into intermittent-phase group and the seizure-phase group. The intermittent-phase group was further divided into a single-focus group and a multiple-foci group according to the number of seizure foci detected by imaging. Following gamma knife treatment, seizure frequency was significantly lower in the intermittent-phase group and the seizure-phase group. Wieser's classification reached Grade I or II in nearly 40% of patients. Seizure frequency was significantly lower following treatment, but Wieser's classification score was significantly higher in the seizure-phase group compared with the intermittent-phase group. Seizure frequency was significantly lower following treatment in the single-focus group, but Wieser's classification score was significantly higher in the single-focus group as compared with the multiple-foci group.
共招募 80 例难治性癫痫患者，来自内蒙古医科大学附属医院。60%的患者病灶可以通过正电子发射断层扫描/CT 成像联合定位。本研究检查了高代谢和低代谢病灶。正电子发射断层扫描/CT 成像显示代谢异常的患者分为间歇期组和发作期组。根据影像学检测到的癫痫灶数量，间歇期组进一步分为单灶组和多灶组。伽玛刀治疗后，间歇期组和发作期组的癫痫发作频率显著降低。近 40%的患者 Wieser 分级达到Ⅰ级或Ⅱ级。治疗后癫痫发作频率显著降低，但发作期组 Wieser 分级评分显著高于间歇期组。单灶组治疗后癫痫发作频率显著降低，但单灶组 Wieser 分级评分显著高于多灶组。
