Nelson N
Roche Institute of Molecular Biology, Roche Research Center, Nutley, New Jersey 07110.
J Bioenerg Biomembr. 1989 Oct;21(5):553-71. doi: 10.1007/BF00808113.
Proton-ATPases can be divided into three classes denoted as P-, F-, and V-ATPases. The P-ATPases are evolutionarily distinct from the F- and V-type ATPases which have been shown to be related, probably evolved from a common ancestral enzyme. Like F-ATPases, V-ATPases are composed of two distinct structures: a catalytic sector that is hydrophilic in nature and a hydrophobic membrane sector which functions in proton conduction. Recent studies on the molecular biology of vacuolar H+-ATPases revealed surprising findings about the evolution of pronon pumps as well as important clues for the evolution of eukaryotic cells.
质子 - ATP酶可分为三类，分别称为P型、F型和V型ATP酶。P型ATP酶在进化上与已被证明相关的F型和V型ATP酶不同，它们可能由一种共同的祖先酶进化而来。与F型ATP酶一样，V型ATP酶由两种不同的结构组成：一种本质上是亲水性的催化部分和一个在质子传导中起作用的疏水性膜部分。最近关于液泡H⁺ - ATP酶分子生物学的研究揭示了有关质子泵进化的惊人发现以及真核细胞进化的重要线索。
