来自加那利群岛一种群体海葵的新型氧化群体海葵胺

New oxidized zoanthamines from a Canary Islands Zoanthus sp.

作者信息

Cen-Pacheco Francisco, Martín Manuel Norte, Fernández José Javier, Hernández Daranas Antonio

机构信息

Institute of Bio-Organic Chemistry "Antonio González", Center for Biomedical Research of the Canary Islands, University of La Laguna, 38206 Tenerife, Spain.

出版信息

Mar Drugs. 2014 Oct 14;12(10):5188-96. doi: 10.3390/md12105188.

DOI:10.3390/md12105188

PMID:25317536

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4210893/

Abstract

Three new norzoanthamine-type alkaloids, named 2-hydroxy-11-ketonorzoan thamide B (1), norzoanthamide B (2) and 15-hydroxynorzoanthamine (3), were isolated from Zoanthus sp. specimens collected at the Canary Islands. Their structures were determined by interpretation of NMR and HR-ESIMS data. Relative configurations of their chiral centers were proposed on the basis of ROESY spectra and by comparison of their spectroscopic data with those of the well-known compound, norzoanthamine.

摘要

从加那利群岛采集的纽扣珊瑚属标本中分离出三种新的去甲佐安他明型生物碱，分别命名为2-羟基-11-酮去甲佐安他酰胺B（1）、去甲佐安他酰胺B（2）和15-羟基去甲佐安他明（3）。通过对核磁共振（NMR）和高分辨电喷雾电离质谱（HR-ESIMS）数据的解析确定了它们的结构。基于旋转框架 Overhauser 效应光谱（ROESY）以及将它们的光谱数据与知名化合物去甲佐安他明的光谱数据进行比较，提出了其手性中心的相对构型。