Stathopoulos Dimitra, Chambers Scott, Adams Louise, Robins-Browne Roy, Miller Christopher, Enke Ya Lang, Wei Benjamin P C, O'Leary Stephen, Cowan Robert, Newbold Carrie
Cochlear Implants Int. 2015 Jul;16(4):201-7. doi: 10.1179/1754762814Y.0000000099. Epub 2014 Oct 15.
To evaluate the potential risk of pneumococcal meningitis associated with the use of a dexamethasone-eluting intracochlear electrode array as compared with a control array.
In two phases, adult Hooded-Wistar rats were implanted via the middle ear with an intracochlear array and were inoculated with Streptococcus pneumoniae 5 days post-surgery. Phase I created a dosing curve by implanting five groups (n = 6) with a control array, then inoculating 5 days later with different numbers of S. pneumoniae: 0 CFU, 10(3) CFU, 10(4) CFU, 10(4) CFU repeated, or 10(5) CFU (colony forming units). A target infection rate of 20% was aimed for and 10(4) CFU was the closest to this target with 33% infection rate. In phase II, we implanted two groups (n = 10), one with a dexamethasone-eluting array, the other a control array, and both groups were inoculated with 10(4) CFU of S. pneumoniae 5 days post-surgery.
The dexamethasone-eluting array group had a 40% infection rate; the control array group had a 60% infection rate. This difference was not statistically significant with a P value of ≥0.5.
The use of a dexamethasone-eluting intracochlear electrode array did not increase the risk of meningitis in rats when inoculated with S. pneumoniae via the middle ear 5 days following implantation.
评估与对照电极阵列相比，使用地塞米松洗脱型人工耳蜗电极阵列引发肺炎球菌性脑膜炎的潜在风险。
分两个阶段，成年Hooded-Wistar大鼠通过中耳植入人工耳蜗电极阵列，并在术后5天接种肺炎链球菌。第一阶段，植入五组（每组n = 6）对照电极阵列以建立给药曲线，然后在5天后接种不同数量的肺炎链球菌：0 CFU、10³ CFU、10⁴ CFU、重复接种10⁴ CFU或10⁵ CFU（菌落形成单位）。目标感染率设定为20%，10⁴ CFU最接近该目标，感染率为33%。在第二阶段，植入两组（每组n = 10），一组植入地塞米松洗脱型电极阵列，另一组植入对照电极阵列，两组均在术后5天接种10⁴ CFU的肺炎链球菌。
地塞米松洗脱型电极阵列组感染率为40%；对照电极阵列组感染率为60%。差异无统计学意义，P值≥0.5。
植入后5天经中耳接种肺炎链球菌时，使用地塞米松洗脱型人工耳蜗电极阵列不会增加大鼠患脑膜炎的风险。
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