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[膜保护剂对急性心肌梗死患者心脏舒张功能的影响]

[Effect of membrane protectors on the diastolic function of the heart in patients with acute myocardial infarction].

作者信息

Dzizinskiĭ A A, Ana'nev A A, Fuks A R

出版信息

Kardiologiia. 1989 Sep;29(9):52-5.

PMID:2531814
Abstract

Apexcardiography was employed to make a noninvasive assessment of left ventricular diastolic function in 80 patients with extensive myocardial infarction. In half the patients, there were impairments in cardiac diastole as manifested by its altered phase structure and some changed parameters indirectly indicating a rise in left ventricular end diastolic pressure and a fall in myocardial relation rates and diastolic compliance. Prior 10-day administration of tocopherol and nicotinamide to 45 patients caused a decrease in the severity of diastolic abnormalities in those in whom the latter had been abnormal. The use of membrane protectors resulted in lower incidence of complications and improved outcome of the disease.

摘要

采用心尖心动图对80例广泛心肌梗死患者的左心室舒张功能进行无创评估。半数患者存在心脏舒张功能障碍,表现为舒张期时相结构改变,一些参数变化间接提示左心室舒张末期压力升高、心肌松弛速率和舒张顺应性降低。对45例患者提前10天给予生育酚和烟酰胺,可使舒张功能异常患者的舒张功能异常严重程度降低。使用膜保护剂可降低并发症发生率,改善疾病预后。

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