血清骨保护素与根据高血压患者的心踝血管指数评估的动脉僵硬度相关。
Serum osteoprotegerin is associated with arterial stiffness assessed according to the cardio-ankle vascular index in hypertensive patients.
作者信息
Lee Chung-Jen, Wang Ji-Hung, Chen Mei-Ling, Yang Chiu-Fen, Chen Yu-Chih, Hsu Bang-Gee
机构信息
Department of Nursing, Tzu Chi College of Technology.
出版信息
J Atheroscler Thromb. 2015;22(3):304-12. doi: 10.5551/jat.25882. Epub 2014 Oct 15.
AIM
Arterial stiffness is recognized to be an independent risk factor for cardiovascular morbidity and mortality. Recent studies have found that osteoprotegerin (OPG) is associated with increased pulse wave velocity and may reflect endothelial dysfunction. The aim of this study was to evaluate the relationship between the serum OPG level and arterial stiffness in hypertensive patients using the cardio-ankle vascular index (CAVI).
METHODS
Fasting blood samples were obtained from 115 hypertensive patients and 52 healthy participants. The CAVI value was derived using the waveform device (CAVI-VaSera VS-1000). The serum OPG levels were measured using a commercially available enzyme-linked immunosorbent assay. A CAVI value of ≥9 defined the high arterial stiffness group.
RESULTS
Sixty-five hypertensive patients (56.5%) were included in the high arterial stiffness group. Diabetes (p=0.032), smoking (p=0.044), age (p < 0.001), systolic blood pressure (p=0.001), diastolic blood pressure (p=0.024), pulse pressure (p=0.046) and the creatinine (p=0.013) and serum OPG (p < 0.001) levels were higher in the high arterial stiffness group than in the low arterial stiffness group, while the glomerular filtration rate (p=0.003) was lower in the high arterial stiffness group than in the low arterial stiffness group among the hypertensive patients. The results of the Spearman's rank correlation coefficient test also indicated a strong positive correlation between the OPG and CAVI values (r=0.484, p < 0.001) in the hypertensive patients. In addition, a multivariate logistic regression analysis showed that age (odds ratio: 1.162, 95% confidence interval (CI): 1.070-1.263, p < 0.001), diastolic blood pressure (odds ratio: 1.109, 95% CI: 1.033-1.190, p=0.004), and serum OPG level (odds ratio: 1.275, 95% CI: 1.030-1.580, p=0.026) were independent predictors of arterial stiffness in hypertensive patients.
CONCLUSIONS
The serum OPG level is positively associated with arterial stiffness in hypertensive patients.
目的
动脉僵硬度被认为是心血管疾病发病和死亡的独立危险因素。最近的研究发现，骨保护素（OPG）与脉搏波速度增加有关，可能反映内皮功能障碍。本研究的目的是使用心踝血管指数（CAVI）评估高血压患者血清OPG水平与动脉僵硬度之间的关系。
方法
从115例高血压患者和52例健康参与者中采集空腹血样。使用波形设备（CAVI-VaSera VS-1000）得出CAVI值。使用市售的酶联免疫吸附测定法测量血清OPG水平。CAVI值≥9定义为高动脉僵硬度组。
结果
65例高血压患者（56.5%）被纳入高动脉僵硬度组。高动脉僵硬度组的糖尿病（p=0.032）、吸烟（p=0.044）、年龄（p<0.001）、收缩压（p=0.001）、舒张压（p=0.024）、脉压（p=0.046）以及肌酐（p=0.013）和血清OPG（p<0.001）水平均高于低动脉僵硬度组，而高血压患者中高动脉僵硬度组的肾小球滤过率（p=0.003）低于低动脉僵硬度组。Spearman等级相关系数检验结果还表明，高血压患者中OPG与CAVI值之间存在强正相关（r=0.484，p<0.001）。此外，多因素逻辑回归分析显示，年龄（比值比：1.162，95%置信区间（CI）：1.070-1.263，p<0.001）、舒张压（比值比：1.109，95%CI：1.033-1.190，p=0.004）和血清OPG水平（比值比：1.275，95%CI：1.030-1.580，p=0.026）是高血压患者动脉僵硬度的独立预测因素。
结论
高血压患者血清OPG水平与动脉僵硬度呈正相关。
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