Second Internal Medicine Department, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.
Maturitas. 2013 Oct;76(2):146-50. doi: 10.1016/j.maturitas.2013.07.001. Epub 2013 Aug 1.
Osteoprotegerin (OPG), osteopontin (OPN) and matrix Gla protein (MGP) are markers of bone metabolism but they are also involved in vascular calcification. However, their precise role is not completely understood. Arterial stiffness is considered an independent predictor of cardiovascular events and it may be one of the causes of the increased cardiovascular risk associated with postmenopausal status. Medial and intimal calcification may increase arterial stiffness. The aim of our study was to assess the relationship of OPG, OPN and MGP with aortic pulse wave velocity (aPWV) as a marker of arterial stiffness in postmenopausal women.
Circulating OPG, OPN and serum total MGP were measured in 144 postmenopausal women using the enzyme-linked immunosorbent assay method. Aortic PWV was determined by an oscillometric method.
Osteoprotegerin correlated with age (p<0.001, r=0.27), aPWV (p<0.001, r=0.32) and hypersensitive C reactive protein (hsCRP) (p<0.001, r=0.37), OPN correlated directly with hsCRP (p<0.001, r=0.39) and inversely with high density lipoprotein cholesterol (p=0.02, r=-0.02). No significant association was found between total MGP and clinical, biochemical and vascular parameters. The correlation between OPG and aPWV persisted even after the adjustment for various potential confounders (p=0.02, r=0.19). In multiple regression analysis in the whole study population the most important predictors of aPWV were OPG (β=0.230, p=0.006), hsCRP (β=0.212, p=0.01) and systolic blood pressure (β=0.163, p=0.04). After exclusion of patients treated with statins the independent predictors were hsCRP (β=0.275, p=0.005) and OPG (β=0.199, p=0.04).
Circulating OPG, but not OPN and total MGP, is associated with aPWV and may be a marker of the increased arterial stiffness and cardiovascular risk in postmenopausal women.
骨保护素（OPG）、骨桥蛋白（OPN）和基质 Gla 蛋白（MGP）是骨代谢的标志物，但它们也参与血管钙化。然而，其确切作用尚不完全清楚。动脉僵硬度被认为是心血管事件的独立预测因子，它可能是绝经后状态相关心血管风险增加的原因之一。中层和内膜钙化可增加动脉僵硬度。本研究旨在评估 OPG、OPN 和 MGP 与作为动脉僵硬度标志物的主动脉脉搏波速度（aPWV）之间的关系在绝经后妇女中。
使用酶联免疫吸附试验法测定 144 例绝经后妇女的循环 OPG、OPN 和血清总 MGP。采用振荡法测定主动脉 PWV。
OPG 与年龄相关（p<0.001，r=0.27）、aPWV（p<0.001，r=0.32）和超敏 C 反应蛋白（hsCRP）（p<0.001，r=0.37），OPN 与 hsCRP 直接相关（p<0.001，r=0.39），与高密度脂蛋白胆固醇呈负相关（p=0.02，r=-0.02）。总 MGP 与临床、生化和血管参数无显著相关性。OPG 与 aPWV 的相关性在调整各种潜在混杂因素后仍然存在（p=0.02，r=0.19）。在整个研究人群的多元回归分析中，aPWV 的最重要预测因子是 OPG（β=0.230，p=0.006）、hsCRP（β=0.212，p=0.01）和收缩压（β=0.163，p=0.04）。排除接受他汀类药物治疗的患者后，独立预测因子为 hsCRP（β=0.275，p=0.005）和 OPG（β=0.199，p=0.04）。
循环 OPG 而不是 OPN 和总 MGP 与 aPWV 相关，可能是绝经后妇女动脉僵硬度和心血管风险增加的标志物。
