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新发现的表皮角质形成细胞中的嗅觉受体与角质形成细胞的增殖、迁移和再上皮化有关。

Newly discovered olfactory receptors in epidermal keratinocytes are associated with proliferation, migration, and re-epithelialization of keratinocytes.

机构信息

Shiseido Research Center, Yokohama, Japan; Japan Science and Technology Agency, CREST, Tokyo, Japan.

出版信息

J Invest Dermatol. 2014 Nov;134(11):2677-2679. doi: 10.1038/jid.2014.229.

DOI:10.1038/jid.2014.229
PMID:25318430
Abstract

Skin contains receptors for various environmental factors. In this issue of the Journal, Busse et al. cloned a new olfactory receptor, OR2AT4, in keratinocytes. They show that the activation of OR2AT4 induces phosphorylation of extracellular signal-regulated kinases and p38 mitogen-activated protein kinases, and that it accelerates wound healing. OR2AT4 may be a promising candidate as a target in clinical drug development.

摘要

皮肤包含各种环境因素的受体。在本期杂志中，Busse 等人在角质形成细胞中克隆了一种新的嗅觉受体 OR2AT4。他们表明，OR2AT4 的激活诱导细胞外信号调节激酶和 p38 丝裂原活化蛋白激酶的磷酸化，并加速伤口愈合。OR2AT4 可能是临床药物开发中一个有前途的靶点候选物。

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本文引用的文献

1
A synthetic sandalwood odorant induces wound-healing processes in human keratinocytes via the olfactory receptor OR2AT4.一种合成檀香气味通过嗅觉受体 OR2AT4 诱导人角质形成细胞的伤口愈合过程。
J Invest Dermatol. 2014 Nov;134(11):2823-2832. doi: 10.1038/jid.2014.273. Epub 2014 Jul 7.
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Expression of odorant receptor family, type 2 OR in the aquatic olfactory cavity of amphibian frog Xenopus tropicalis.表达气味受体家族，2 型 OR 在两栖类青蛙 Xenopus tropicalis 的水生嗅觉腔中。
PLoS One. 2012;7(4):e33922. doi: 10.1371/journal.pone.0033922. Epub 2012 Apr 11.
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Roles of transient receptor potential proteins (TRPs) in epidermal keratinocytes.
具有微生物功能的 3D 皮肤：一种揭示宿主-微生物相互作用及其潜在毒理学影响的测试系统。
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Sandalwood Album Oil as a Botanical Therapeutic in Dermatology.檀香木精油作为皮肤科的一种植物疗法。
J Clin Aesthet Dermatol. 2017 Oct;10(10):34-39. Epub 2017 Oct 1.
瞬时受体电位蛋白（TRP）在表皮角质形成细胞中的作用。
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Skin cancer chemoprevention by α-santalol.α-檀香醇对皮肤癌的化学预防作用。
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TRP channel regulates EGFR signaling in hair morphogenesis and skin barrier formation.TRP 通道调节毛发形态发生和皮肤屏障形成中的 EGFR 信号传导。
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