Froeling Fieke E M, Seckl Michael J
Department of Medical Oncology, Charing Cross Gestational Trophoblastic Disease Centre, Imperial College Healthcare NHS Trust and Imperial College London, Fulham Palace Road, London, W6 8RF, UK.
Curr Oncol Rep. 2014 Nov;16(11):408. doi: 10.1007/s11912-014-0408-y.
Gestational trophoblastic disease describes a variety of pregnancy-related diseases including the premalignant conditions of a partial and complete hydatidiform mole and the malignant disorders of invasive mole, choriocarcinoma and the rare placental-site trophoblastic tumour and epithelioid trophoblastic tumour. The availability of a highly sensitive tumour marker in the form of human chorionic gonadotrophin, the chemosensitive character of the disease with effective treatment strategies and centralization of care of a rare group of diseases has resulted in excellent survival rates, which can exceed 98 %. This review gives a general overview of gestational trophoblastic disease, the most recent insights in aetiology and pathology and a summary of the different management strategies.
妊娠滋养细胞疾病描述了多种与妊娠相关的疾病，包括部分性和完全性葡萄胎的癌前病变以及侵蚀性葡萄胎、绒毛膜癌、罕见的胎盘部位滋养细胞肿瘤和上皮样滋养细胞肿瘤等恶性疾病。以人绒毛膜促性腺激素形式存在的高敏感性肿瘤标志物、有效治疗策略下疾病的化疗敏感性以及对这一罕见疾病群体的集中护理，使得生存率极高，可超过98%。本综述对妊娠滋养细胞疾病、病因学和病理学的最新见解以及不同管理策略进行了概述。
