The asymmetric alkylation of dimethylhydrazones; intermolecular chirality transfer using sparteine as chiral ligand.
作者信息
McSweeney Christina M, Foley Vera M, McGlacken Gerard P
机构信息
Analytical and Biological Chemistry Research Facility and Department of Chemistry, University College Cork, Cork, Ireland.
出版信息
Chem Commun (Camb). 2014 Dec 7;50(94):14817-9. doi: 10.1039/c4cc06895e.
PMID:25318599
Abstract
The asymmetric alkylation of ketones represents a fundamental transformation in organic chemistry. Chiral auxiliaries have been used almost exclusively for this transformation. Herein we describe a strategy for the generation of enantiomerically enriched α-alkylated ketones up to an er of 83 : 17, using a chiral ligand protocol.
摘要
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