Hacini J, Berthoux P, Guerin C, Charrere G, Ville G, Berthoux F C
Service de Néphrologie, CHU de Saint-Etienne, Hôpital Nord, Saint-Priest-en-Jarez.
Presse Med. 1989 Nov 25;18(39):1913-6.
In a longitudinal study, 53 renal allograft recipients were investigated for changes in serum creatinine and neopterin levels and in the neopterin/creatinine (N/C) ratio which makes it possible to disregard the glomerular filtration level. The patients were divided into 5 groups according to their clinical situation: stability, acute renal failure due to acute tubular necrosis, acute graft rejection, bacterial or viral infection and cyclosporin overdosage. Only N/C discriminated between these situations, being normal (less than 200.10(-6) in groups 1 and 2, significantly elevated in groups 3 and 4 and low in group 5. The highest N/C value was observed in patients with primary cytomegalovirus infection. It is concluded that the N/C ratio is a good biochemical parameter to be used in the follow-up of renal allograft recipients.
在一项纵向研究中，对53名肾移植受者的血清肌酐、新蝶呤水平以及新蝶呤/肌酐（N/C）比值的变化进行了调查，该比值能够忽略肾小球滤过水平。根据临床情况，患者被分为5组：稳定组、急性肾小管坏死所致急性肾衰竭组、急性移植排斥组、细菌或病毒感染组以及环孢素过量组。只有N/C比值能够区分这些情况，在第1组和第2组中正常（低于200×10⁻⁶），在第3组和第4组中显著升高，在第5组中较低。原发性巨细胞病毒感染患者的N/C值最高。结论是，N/C比值是用于肾移植受者随访的良好生化参数。
