Mount David B
Renal Division, Brigham and Women's Hospital, Veterans Affairs Boston Healthcare System, Boston, Massachusetts
Clin J Am Soc Nephrol. 2014 Nov 7;9(11):1974-86. doi: 10.2215/CJN.04480413. Epub 2014 Oct 15.
The thick ascending limb occupies a central anatomic and functional position in human renal physiology, with critical roles in the defense of the extracellular fluid volume, the urinary concentrating mechanism, calcium and magnesium homeostasis, bicarbonate and ammonium homeostasis, and urinary protein composition. The last decade has witnessed tremendous progress in the understanding of the molecular physiology and pathophysiology of this nephron segment. These advances are the subject of this review, with emphasis on particularly recent developments.
髓袢升支粗段在人体肾脏生理学中占据核心的解剖学和功能位置，在细胞外液量的维持、尿液浓缩机制、钙和镁的稳态、碳酸氢盐和铵的稳态以及尿蛋白组成方面发挥着关键作用。在过去十年中，人们对这个肾单位节段的分子生理学和病理生理学的理解取得了巨大进展。这些进展是本综述的主题，重点是特别近期的发展。
