Burg M B
Kidney Int. 1982 Nov;22(5):454-64. doi: 10.1038/ki.1982.198.
Thick ascending limbs of Henle's loop have at least three major roles: (1) They reabsorb sodium chloride which dilutes the urine. (2) The reabsorption of sodium chloride also produces concentration gradients that drive the countercurrent multiplier system in the medulla and medullary rays and thus concentrates the urine. (3) They reabsorb large amounts of potassium, calcium, and magnesium in an energy-efficient manner. The mechanisms involved in these functions are reviewed in this paper, emphasizing the results of direct studies on isolated tubule segments.
（1）它们重吸收氯化钠，从而稀释尿液。（2）氯化钠的重吸收还产生浓度梯度，驱动髓质和髓放线中的逆流倍增系统，进而浓缩尿液。（3）它们以高效节能的方式重吸收大量的钾、钙和镁。本文综述了这些功能所涉及的机制，重点介绍了对分离肾小管节段的直接研究结果。
