Zhou Feng, Gou Shan-Miao, Xiong Jiong-Xin, Wu He-Shui, Wang Chun-You, Liu Tao
Pancreatic Disease Institute, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
J Huazhong Univ Sci Technolog Med Sci. 2014 Oct;34(5):701-705. doi: 10.1007/s11596-014-1339-4. Epub 2014 Oct 16.
The main treatment strategies for chronic pancreatitis in young patients include therapeutic endoscopic retrograde cholangio-pancreatography (ERCP) intervention and surgical intervention. Therapeutic ERCP intervention is performed much more extensively for its minimally invasive nature, but a part of patients are referred to surgery at last. Historical and follow-up data of 21 young patients with chronic pancreatitis undergoing duodenum-preserving total pancreatic head resection were analyzed to evaluate the outcomes of therapeutic ERCP intervention and surgical intervention in this study. The surgical complications of repeated therapeutic ERCP intervention and surgical intervention were 38% and 19% respectively. During the first therapeutic ERCP intervention to surgical intervention, 2 patients developed diabetes, 5 patients developed steatorrhea, and 5 patients developed pancreatic type B pain. During the follow-up of surgical intervention, 1 new case of diabetes occurred, 1 case of steatorrhea recovered, and 4 cases of pancreatic type B pain were completely relieved. In a part of young patients with chronic pancreatitis, surgical intervention was more effective than therapeutic ERCP intervention on delaying the progression of the disease and relieving the symptoms.
年轻患者慢性胰腺炎的主要治疗策略包括治疗性内镜逆行胰胆管造影（ERCP）介入和手术介入。治疗性ERCP介入因其微创性而应用更为广泛，但一部分患者最终还是接受了手术治疗。分析了21例接受保留十二指肠的全胰头切除术的年轻慢性胰腺炎患者的历史和随访数据，以评估本研究中治疗性ERCP介入和手术介入的效果。重复治疗性ERCP介入和手术介入的手术并发症分别为38%和19%。在首次治疗性ERCP介入至手术介入期间，2例患者出现糖尿病，5例患者出现脂肪泻，5例患者出现B型胰性疼痛。在手术介入的随访期间，出现1例新的糖尿病病例，1例脂肪泻恢复，4例B型胰性疼痛完全缓解。在一部分年轻慢性胰腺炎患者中，手术介入在延缓疾病进展和缓解症状方面比治疗性ERCP介入更有效。
