大肠杆菌O174菌株O抗原四糖重复单元的高效合成。
Efficient synthesis of the tetrasaccharide repeating unit of the O-antigen of Escherichia coli O174 strain.
作者信息
Bhaumik Ishani, Ghosh Tamashree, Misra Anup Kumar
机构信息
Bose Institute, Division of Molecular Medicine, P-1/12, C.I.T. Scheme VII-M, Kolkata 700054, India.
Bose Institute, Division of Molecular Medicine, P-1/12, C.I.T. Scheme VII-M, Kolkata 700054, India.
出版信息
Carbohydr Res. 2014 Nov 18;399:21-5. doi: 10.1016/j.carres.2014.08.003. Epub 2014 Aug 12.
The tetrasaccharide repeating unit of the O-antigen of Escherichia coli O174 strain was synthesized applying sequential glycosylations of suitably functionalized monosaccharide intermediates. Activation of glycosyl trichloroacetimidate derivatives using nitrosyl tetrafluoroborate (NOBF4) has been used during the synthesis. The glycosylation steps were high yielding with satisfactory stereo outcome.
通过对适当官能化的单糖中间体进行连续糖基化反应，合成了大肠杆菌O174菌株O抗原的四糖重复单元。合成过程中使用了四氟硼酸亚硝酰（NOBF4）对糖基三氯乙酰亚胺衍生物进行活化。糖基化步骤产率高，立体化学结果令人满意。
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