大肠杆菌 O128 抗原五糖重复单元的合成。
Synthesis of the pentasaccharide repeating unit of Escherichia coli O128 antigen.
机构信息
State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China.
出版信息
Carbohydr Res. 2010 Oct 13;345(15):2272-6. doi: 10.1016/j.carres.2010.07.025. Epub 2010 Jul 21.
A pentasaccharide, 4-methoxyphenyl 2-acetamido-2-deoxy-β-d-galactopyranosyl-(1→4)-α-d-galactopyranosyl-(1→3)-2-acetamido-2-deoxy-β-d-galactopyranosyl-(1→6)-[α-l-fucopyranosyl-(1→2)]-β-d-galactopyranoside (1), representing the repeating unit of Escherichia coli O128 antigen, was successfully prepared in 23% overall yield via a convergent '2+3' glycosylation strategy.
一种五糖，4-甲氧基苯基 2-乙酰氨基-2-去氧-β-d-半乳糖吡喃基-(1→4)-α-d-半乳糖吡喃基-(1→3)-2-乙酰氨基-2-去氧-β-d-半乳糖吡喃基-(1→6)-[α-l-岩藻吡喃基-(1→2)]-β-d-半乳糖吡喃苷（1），代表大肠杆菌 O128 抗原的重复单元，通过收敛的“2+3”糖苷化策略，以 23%的总收率成功制备。
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