Buigues Cristina, Padilla-Sánchez Celia, Garrido Julio Fernández, Navarro-Martínez Rut, Ruiz-Ros Vicente, Cauli Omar
a Department of Nursing , University of Valencia , Valencia , Spain.
Aging Ment Health. 2015;19(9):762-72. doi: 10.1080/13607863.2014.967174. Epub 2014 Oct 16.
Frailty is a geriatric syndrome characterised by the clinical presentation of identifiable physical alterations such as loss of muscle mass and strength, energy and exercise tolerance, and decreased physiological reserve. Frailty and depressive symptoms are common issues facing older adults and may be associated. It is not clear if the depression facilitates the appearance of frailty syndrome or vice versa or these two coexist independently in the same individuals.
We performed searches in several databases (Embase, PubMed, CINAHL, Scopus, and PsycINFO) papers published between November 2003 to February 2014 about frailty syndrome and depression in people aged 65 and older published and the reference lists of from the articles retrieved were pearled in order to identify any which may have been missed in the initial search. Two independent reviewers extracted descriptive information on the prevalence and co-occurrence of frailty and depression in older individuals and of frailty criteria among depressed patients.
Depression and frailty occur in a significant proportion of frail older individuals. Common pathophysiological alterations and biomarkers in the two syndromes have been recently described.
Studies on the causal relationship between the two syndromes are clearly necessary in the future.
衰弱是一种老年综合征，其临床表现为可识别的身体改变，如肌肉质量和力量丧失、精力和运动耐力下降以及生理储备减少。衰弱和抑郁症状是老年人面临的常见问题，且可能存在关联。目前尚不清楚是抑郁促使衰弱综合征的出现，还是反之，亦或是这两者在同一人群中独立共存。
我们在多个数据库（Embase、PubMed、CINAHL、Scopus和PsycINFO）中检索了2003年11月至2014年2月期间发表的有关65岁及以上人群衰弱综合征和抑郁的论文，并梳理了检索到文章的参考文献列表，以识别在初始检索中可能遗漏的任何文献。两名独立评审员提取了关于老年人衰弱和抑郁的患病率及共现情况，以及抑郁症患者中衰弱标准的描述性信息。
抑郁和衰弱在相当一部分衰弱老年人中存在。最近已描述了这两种综合征常见的病理生理改变和生物标志物。
未来显然有必要开展关于这两种综合征因果关系的研究。
