阿尔茨海默型痴呆患者脊髓中的胆碱能酶
Cholinergic enzymes in the spinal cord in Alzheimer-type dementia.
作者信息
Yates C M, Simpson J, Gordon A, Christie J E
机构信息
Department of Pharmacology, Edinburgh University, UK.
出版信息
J Neural Transm Park Dis Dement Sect. 1989;1(4):311-5. doi: 10.1007/BF02263485.
Choline acetyltransferase (ChAT) and acetylcholinesterase (AChE) were measured in anterior and posterior grey matter of the lumbar spinal cord and in temporal and frontal cortex from six cases of Alzheimer-type dementia (ATD), one case of Down's syndrome, three cases of schizophrenia (SZ) and six controls. Compared with control and SZ values, ChAT and AChE were reduced in ATD cerebral cortex. ChAT was reduced, and AChE unaltered, in ATD spinal cord. Decreased cord ChAT may be related to electrophysiological abnormalities which have been reported in motor nerves of patients with Alzheimer's disease.
在6例阿尔茨海默型痴呆（ATD）、1例唐氏综合征、3例精神分裂症（SZ）患者及6名对照者中，检测了腰段脊髓前后灰质以及颞叶和额叶皮质中的胆碱乙酰转移酶（ChAT）和乙酰胆碱酯酶（AChE）。与对照者和SZ患者的值相比，ATD患者大脑皮质中的ChAT和AChE降低。ATD患者脊髓中的ChAT降低，而AChE未改变。脊髓ChAT降低可能与阿尔茨海默病患者运动神经中报道的电生理异常有关。
Zotero 插件