Lohsiriwat Varut
Varut Lohsiriwat, Division of Colon and Rectal Surgery, Department of Surgery, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand.
World J Gastroenterol. 2014 Oct 14;20(38):13950-5. doi: 10.3748/wjg.v20.i38.13950.
To investigate the feasibility and beneficial effects of enhanced recovery after surgery (ERAS) programme in the setting of emergency colorectal surgery.
Between January 2011 and October 2013, patients undergoing emergency resection for obstructing colorectal cancer at the Faculty of Medicine Siriraj Hospital, Bangkok, Thailand using ERAS programme were compared with those using conventional care (1:2 ratio). They were matched for their age, gender, ColoRectal Physiological and Operative Severity Score for the enUmeration of Mortality and Morbidity score, and type of surgery. Primary outcomes were length of hospital stay and postoperative morbidity. Secondary outcomes included gastrointestinal recovery, 30-d readmission, and time interval from surgery to chemotherapy.
Twenty patients treated with ERAS programme were compared with 40 patients receiving conventional postoperative care. Median of hospital stay was shorter in the ERAS group: 5.5 d (range: 3-16) vs 7.5 d (range: 5-25), P = 0.009. The ERAS group had a non-significant reduction in the incidence of postoperative complication (25% vs 48%, P = 0.094). No 30-d mortality and readmission occurred. Patients with ERAS programme had a shorter time to first flatus (1.6 d vs 2.8 d, P < 0.001) and time to resumption of normal diet (3.5 d vs 5.5 d, P = 0.002). Time interval between operation and initiation of adjuvant chemotherapy was significantly shorter in the ERAS group (37 d vs 49 d, P = 0.009).
The ERAS programme in the setting of emergency colorectal surgery was safe and feasible. It achieved significantly shorter hospitalisation and faster recovery of bowel function.
探讨加速康复外科(ERAS)方案在急诊结直肠手术中的可行性及有益效果。
2011年1月至2013年10月,在泰国曼谷诗里拉吉医院医学院,将采用ERAS方案进行急诊结直肠癌梗阻切除术的患者与采用传统护理的患者(比例为1:2)进行比较。根据年龄、性别、结直肠生理和手术严重程度评分(用于计算死亡率和发病率)以及手术类型进行匹配。主要结局指标为住院时间和术后发病率。次要结局指标包括胃肠道恢复情况、30天再入院率以及手术至化疗的时间间隔。
20例接受ERAS方案治疗的患者与40例接受传统术后护理的患者进行了比较。ERAS组的中位住院时间较短:5.5天(范围:3 - 16天) vs 7.5天(范围:5 - 25天),P = 0.009。ERAS组术后并发症发生率有非显著性降低(25% vs 48%,P = 0.094)。未发生30天死亡率和再入院情况。采用ERAS方案的患者首次排气时间较短(1.6天 vs 2.8天,P < 0.001),恢复正常饮食时间较短(3.5天 vs 5.5天,P = 0.002)。ERAS组手术至辅助化疗开始的时间间隔显著缩短(37天 vs 49天,P = 0.009)。
急诊结直肠手术中的ERAS方案安全可行。它显著缩短了住院时间,加快了肠功能恢复。