改良的术后加速康复方案对接受结直肠癌梗阻急诊手术的患者术后恢复有益:一项倾向评分匹配分析。
Modified enhanced recovery after surgery protocols are beneficial for postoperative recovery for patients undergoing emergency surgery for obstructive colorectal cancer: A propensity score matching analysis.
作者信息
Shang Yuanyuan, Guo Chunbao, Zhang Dianliang
机构信息
Department of Colorectal Surgery, Qingdao Municipal Hospital, Qingdao University, Qingdao.
Department of Pediatric General Surgery.
出版信息
Medicine (Baltimore). 2018 Sep;97(39):e12348. doi: 10.1097/MD.0000000000012348.
Enhanced recovery after surgery (ERAS) is acknowledged to reduce perioperative stress in several surgical diseases. Here, we investigated whether modified ERAS is associated with beneficial effects in the setting of emergency colorectal surgery.We retrospectively evaluated the medical records of 839 consecutive patients with obstructive colorectal cancer undergoing surgical intervention at 4 institutes. Among them, 356 cases were managed with a multidisciplinary team approach to care (modified ERAS protocols), and the remaining 483 cases were treated based on traditional protocols. According to modified ERAS or traditional care, propensity score (PS) matching was performed to adjust biases in patient selection. The primary outcome was gastrointestinal function recovery. Secondary outcomes included postoperative complications and length of hospital stay.Modified ERAS was associated with postoperative gastrointestinal function recovery, including time to first flatus (P = .002), first defecation (P = .008), and prolonged ileus (P = .016). According to the Clavien-Dindo classification, fewer total episodes of grade II or higher postoperative complications were observed in patients cared for with modified ERAS than in patients with traditional care (P = .002). Median (interquartile range) postoperative hospital stay in the modified ERAS group was 6 (3-22) days versus 9 (7-27) days in the traditional care group (P < .001). Furthermore, the interval from operation to postoperative chemotherapy (d) was significantly shorter in the modified ERAS group (35.6 ± 11.5 vs 47.6 ± 23.8, P < .001).The modified ERAS was safe and associated with clinical benefits, including fast recovery of bowel function, reduced postoperative complications, and shorter hospital stay for patients with obstructive colorectal cancer.
术后加速康复(ERAS)被认为可减轻多种外科疾病的围手术期应激。在此,我们研究了改良的ERAS在急诊结直肠手术中的应用是否具有有益效果。我们回顾性评估了4家机构连续839例接受手术干预的梗阻性结直肠癌患者的病历。其中,356例采用多学科团队护理方法(改良ERAS方案)进行管理,其余483例根据传统方案进行治疗。根据改良ERAS或传统护理,进行倾向评分(PS)匹配以调整患者选择中的偏差。主要结局是胃肠功能恢复。次要结局包括术后并发症和住院时间。改良ERAS与术后胃肠功能恢复相关,包括首次排气时间(P = 0.002)、首次排便时间(P = 0.008)和肠梗阻持续时间(P = 0.016)。根据Clavien-Dindo分类,接受改良ERAS护理的患者术后Ⅱ级或更高等级并发症的总发生率低于接受传统护理的患者(P = 0.002)。改良ERAS组术后住院时间的中位数(四分位间距)为6(3 - 22)天,而传统护理组为9(7 - 27)天(P < 0.001)。此外,改良ERAS组从手术到术后化疗的间隔时间(天)明显更短(35.6 ± 11.5 vs 47.6 ± 23.8,P < 0.001)。改良ERAS是安全的,并且与临床益处相关,包括肠功能快速恢复、术后并发症减少以及梗阻性结直肠癌患者住院时间缩短。