心房利钠因子可减弱家兔后肢血管系统的交感神经效应反应。

Atrial natriuretic factor attenuates sympathetic neuroeffector responses in hindlimb vasculature of rabbits.

作者信息

Patel K P

机构信息

Department of Physiology, University of South Dakota, Vermillion 57069.

出版信息

Can J Physiol Pharmacol. 1989 Sep;67(9):1101-5. doi: 10.1139/y89-174.

DOI:10.1139/y89-174

PMID:2532057

Abstract

To determine whether atrial natriuretic factor (ANF) affects vasoconstrictor responses to electrical stimulation of sympathetic nerves or intra-arterial norepinephrine (NE), changes in perfusion pressure were measured during lumbar sympathetic nerve stimulation (LSNS, 1-8 Hz), or administration of NE (50-200 ng), in an isolated constant flow-perfused hindlimb of chloralose-anesthetized rabbit before and after intra-arterial infusion of ANF (0.5 ng.mL-1.min-1). ANF significantly attenuated responses to LSNS (relative potency, RP = 0.65) and to NE (RP = 0.47). We conclude that ANF attenuates vasoconstrictor responses to both LSNS and NE. Thus ANF alters sympathetic nervous system mediated changes in vascular resistance possibly at the neuroeffector site.

摘要

为了确定心房利钠因子（ANF）是否影响对交感神经电刺激或动脉内去甲肾上腺素（NE）的血管收缩反应，在氯醛糖麻醉的家兔的离体恒流灌注后肢中，于动脉内输注ANF（0.5 ng·mL⁻¹·min⁻¹）前后，测量了腰交感神经刺激（LSNS，1 - 8 Hz）或给予NE（50 - 200 ng）期间的灌注压变化。ANF显著减弱了对LSNS的反应（相对效能，RP = 0.65）和对NE的反应（RP = 0.47）。我们得出结论，ANF减弱了对LSNS和NE的血管收缩反应。因此，ANF可能在神经效应部位改变交感神经系统介导的血管阻力变化。