用于高分辨率相干反斯托克斯拉曼散射（CARS）显微镜的基于光纤的光学参量振荡器。

Fiber-based optical parametric oscillator for high resolution coherent anti-Stokes Raman scattering (CARS) microscopy.

作者信息

Gottschall Thomas, Meyer Tobias, Baumgartl Martin, Dietzek Benjamin, Popp Jürgen, Limpert Jens, Tünnermann Andreas

出版信息

Opt Express. 2014 Sep 8;22(18):21921-8. doi: 10.1364/OE.22.021921.

DOI:10.1364/OE.22.021921

Abstract

Imaging based on coherent anti-Stokes Raman scattering (CARS) relies on the interaction of high peak-power, synchronized picosecond pulses with narrow bandwidths and a well-defined frequency difference. Recently a new type of fiber-based CARS laser source based on four-wave-mixing (FWM) has been developed. In order to enhance its spectral resolution and efficiency, a FWM based fiber optical parametric oscillator (FOPO) is proposed in this work. The source delivers 180 mW with 5.6 kW peak power for the CARS pump and 130 mW with 2.9 kW peak power for the Stokes signal. CARS resonances around 2850 and 2930 cm(-1) can be resolved with a resolution of 1 cm(-1) enabling high-contrast, spectrally resolved CARS imaging of biological tissue.

摘要

基于相干反斯托克斯拉曼散射（CARS）的成像依赖于高峰值功率、具有窄带宽和明确频率差的同步皮秒脉冲之间的相互作用。最近，一种基于四波混频（FWM）的新型光纤CARS激光源被开发出来。为了提高其光谱分辨率和效率，本文提出了一种基于FWM的光纤光学参量振荡器（FOPO）。该光源为CARS泵浦提供180 mW的功率和5.6 kW的峰值功率，为斯托克斯信号提供130 mW的功率和2.9 kW的峰值功率。在2850和2930 cm(-1)附近的CARS共振可以以1 cm(-1)的分辨率分辨出来，从而实现对生物组织的高对比度、光谱分辨的CARS成像。