早期绝经预防研究（POEMS）：促性腺激素释放激素类似物（GnRHa）能否保留卵巢功能？
Prevention of Early Menopause Study (POEMS): is it possible to preserve ovarian function by gonadotropin releasing hormone analogs (GnRHa)?
作者信息
Gerber B, Ortmann O
机构信息
Department of Gynaecology and Obstetrics, University of Rostock, Klinikum Südstadt, Südring 81, Rostock, 18059, Germany,
出版信息
Arch Gynecol Obstet. 2014 Dec;290(6):1051-3. doi: 10.1007/s00404-014-3493-0.
INTRODUCTION
The effect of GnRHa in the preservation of ovarian function during a modern chemotherapy is still under discussion.
MATERIAL AND METHOD
In this News and Views article, we discuss the benefits and weaknesses of the recently presented POEMS.
RESULTS
The POEM study demonstrated an increased resumption of ovarian function and pregnancy rate after using GnRHa. GnRHa in HR-negative patients led to a significant increase in disease free and overall survival, with those effects being inexplicable. Weaknesses of the trial were prematurely close due to lack of recruitment, a drop-out rate of 38 % during follow-up and definition of hormone receptor negativity by <10 % positive stained cells.
CONCLUSION
Even after POEMS, there is no additional clarity regarding preservation of ovarian function during chemotherapy by GnRHa.
引言
促性腺激素释放激素类似物（GnRHa）在现代化疗期间对卵巢功能的保护作用仍在讨论中。
材料与方法
在这篇新闻与观点文章中，我们讨论了最近提出的POEMS的优点和缺点。
结果
POEM研究表明，使用GnRHa后卵巢功能恢复和妊娠率增加。HR阴性患者使用GnRHa可显著提高无病生存率和总生存率，但其作用机制尚不清楚。该试验的缺点是由于招募不足而提前结束，随访期间的脱落率为38%，且激素受体阴性的定义为阳性染色细胞<10%。
结论
即使在POEMS研究之后，关于GnRHa在化疗期间保护卵巢功能的问题仍未进一步明确。
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