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SGoF多重检验程序的校正p值。

Adjusted p-values for SGoF multiple test procedure.

作者信息

Castro-Conde Irene, de Uña-Álvarez Jacobo

机构信息

SiDOR Research Group, University of Vigo, Facultade de CC Económicas e Empresariais, Campus Lagoas-Marcosende, 36310 Vigo, Spain.

出版信息

Biom J. 2015 Jan;57(1):108-22. doi: 10.1002/bimj.201300238. Epub 2014 Oct 17.

DOI:10.1002/bimj.201300238
PMID:25323102
Abstract

In the field of multiple comparison procedures, adjusted p-values are an important tool to evaluate the significance of a test statistic while taking the multiplicity into account. In this paper, we introduce adjusted p-values for the recently proposed Sequential Goodness-of-Fit (SGoF) multiple test procedure by letting the level of the test vary on the unit interval. This extends previous research on the SGoF method, which is a method of high interest when one aims to increase the statistical power in a multiple testing scenario. The adjusted p-value is the smallest level at which the SGoF procedure would still reject the given null hypothesis, while controlling for the multiplicity of tests. The main properties of the adjusted p-values are investigated. In particular, we show that they are a subset of the original p-values, being equal to 1 for p-values above a certain threshold. These are very useful properties from a numerical viewpoint, since they allow for a simplified method to compute the adjusted p-values. We introduce a modification of the SGoF method, termed majorant version, which rejects the null hypotheses with adjusted p-values below the level. This modification rejects more null hypotheses as the level increases, something which is not in general the case for the original SGoF. Adjusted p-values for the conservative version of the SGoF procedure, which estimates the variance without assuming that all the null hypotheses are true, are also included. The situation with ties among the p-values is discussed too. Several real data applications are investigated to illustrate the practical usage of adjusted p-values, ranging from a small to a large number of tests.

摘要

在多重比较程序领域,调整后的p值是一种重要工具,用于在考虑多重性的情况下评估检验统计量的显著性。在本文中,我们通过让检验水平在单位区间上变化,为最近提出的顺序拟合优度(SGoF)多重检验程序引入调整后的p值。这扩展了先前对SGoF方法的研究,当旨在在多重检验场景中提高统计功效时,SGoF方法是一个备受关注的方法。调整后的p值是SGoF程序在控制检验多重性的同时仍会拒绝给定原假设的最小水平。我们研究了调整后p值的主要性质。特别是,我们表明它们是原始p值的一个子集,对于高于某个阈值的p值等于1。从数值角度来看,这些是非常有用的性质,因为它们允许采用一种简化方法来计算调整后的p值。我们引入了SGoF方法的一种修改形式,称为主版本方法,它以低于该水平的调整后p值拒绝原假设。随着水平的增加,这种修改形式会拒绝更多的原假设,而对于原始SGoF方法通常并非如此。我们还包括了SGoF程序保守版本的调整后p值,该版本在不假设所有原假设都为真的情况下估计方差。我们也讨论了p值存在 ties 的情况。我们研究了几个实际数据应用,以说明调整后p值的实际用途,涵盖从少量到大量检验的情况。

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