Fine Nowell M, Chen Libo, Bastiansen Paul M, Frantz Robert P, Pellikka Patricia A, Oh Jae K, Kane Garvan C
Division of Cardiovascular Diseases, Department of Medicine, Mayo Clinic, Rochester, Minnesota.
Echocardiography. 2015 May;32(5):787-96. doi: 10.1111/echo.12806. Epub 2014 Oct 17.
Myocardial strain imaging is a sensitive echocardiographic technique for identifying ventricular dysfunction. The aim of this study was to describe a reference range for right ventricular (RV) strain in subjects without cardiopulmonary disease and to report these values from a systematic review and meta-analysis of the current literature.
Prospective online measurement of RV free wall longitudinal systolic strain using speckle tracking echocardiography (STE) was performed in 116 subjects with normal echocardiograms and without cardiopulmonary disease or risk factors. A systematic search of studies in EMBASE and Medline reporting RV strain values was performed through February 2014.
The mean age was 48 ± 16 years and 58% were female. Mean RV strain was -26 ± 4%. Ten studies involving a total of 486 patients met our inclusion criteria. The mean age range was 43-57 years and 59% were female. All prior studies were performed with offline strain analysis, and 9 used a GE Healthcare strain analysis software system. The weighted estimate of RV free wall strain measured using tissue Doppler imaging (4 studies) was -27 ± 1% (95% confidence interval [CI] -30% to -25%) and with STE (8 studies, including the current study data) -27 ± 2% (95% CI -29% to -24%), respectively.
A reference range for RV strain in subjects without cardiopulmonary disease is presented. These data may help facilitate the routine clinical measurement of RV strain in patients referred for right heart echocardiography assessment.
心肌应变成像是一种用于识别心室功能障碍的敏感超声心动图技术。本研究的目的是描述无心肺疾病受试者右心室（RV）应变的参考范围，并通过对当前文献的系统评价和荟萃分析报告这些值。
对116名超声心动图正常、无心肺疾病或危险因素的受试者进行斑点追踪超声心动图（STE）对右心室游离壁纵向收缩期应变的前瞻性在线测量。截至2014年2月，对EMBASE和Medline中报告右心室应变值的研究进行了系统检索。
平均年龄为48±16岁，58%为女性。平均右心室应变率为-26±4%。10项研究共纳入486例患者，符合我们的纳入标准。平均年龄范围为43-57岁，59%为女性。所有先前的研究均采用离线应变分析，9项研究使用了通用电气医疗集团的应变分析软件系统。使用组织多普勒成像测量的右心室游离壁应变的加权估计值（4项研究）为-27±1%（95%置信区间[CI]-30%至-25%），使用STE测量的加权估计值（8项研究，包括本研究数据）为-27±2%（95%CI-29%至-24%）。
给出了无心肺疾病受试者右心室应变的参考范围。这些数据可能有助于促进转诊进行右心超声心动图评估的患者右心室应变的常规临床测量。
