WEILL CORNELL MEDICAL COLLEGE.
Blood. 2014 Oct 16;124(16):2471-2. doi: 10.1182/blood-2014-08-590364.
In this issue of Blood, Tefferi et al make the important observations that polycythemia vera (PV) is not a continuum from essential thrombocythemia (ET), that survival in ET is less than matched controls but of longer duration than in patients with PV and primary myelofibrosis (PMF), and that “triple negative” mutational status in PMF is an important adverse risk factor for blast transformation. Genetic profiling should be integrated into classical methods for profiling these diseases
在本期《Blood》中，Tefferi 等人观察到重要的现象，即真性红细胞增多症（PV）并非从特发性血小板增多症（ET）连续发展而来，ET 的生存率虽不及匹配对照组，但持续时间长于 PV 和原发性骨髓纤维化（PMF）患者，PMF 中的“三阴性”突变状态是向白血病转化的重要不良风险因素。遗传分析应该与这些疾病的经典分析方法相结合。
