幼年和成年大鼠对间歇性高海拔低氧心肺反应的比较。
Comparison of cardiopulmonary response to intermittent high-altitude hypoxia in young and adult rats.
作者信息
Kolár F, Ostádal B, Procházka J, Pelouch V, Widimský J
机构信息
Institute of Physiology, Czechoslovak Academy of Sciences, Prague.
出版信息
Respiration. 1989;56(1-2):57-62. doi: 10.1159/000195778.
Haemodynamic and heart weight parameters were compared in male rats exposed to intermittent high-altitude (IHA) hypoxia (barochamber, 8 h/day, 5 days/week, total of 24 exposures stepwise up to 7,000 m) starting either from the 4th day or the 12th week of postnatal life. Systemic arterial pressure and heart rate increased in adult IHA acclimatized animals only. Marked chronic pulmonary hypertension and right ventricular enlargement were found in both age groups. Right ventricular weight increased linearly with a rise of pulmonary blood pressure in animals exposed to IHA from the 4th day of life (r = 0.72); no significant relation was found in adult rats (r = 0.16). The close correlation between both variables in young hypoxic rats may be due to the ability of the developing heart to respond to chronic hypoxia by both hypertrophy and hyperplasia of myocytes.
对出生后第4天或第12周开始暴露于间歇性高海拔（IHA）低氧环境（气压舱，每天8小时，每周5天，共24次暴露，逐步升至7000米）的雄性大鼠的血流动力学和心脏重量参数进行了比较。仅成年IHA适应动物的全身动脉压和心率升高。在两个年龄组中均发现明显的慢性肺动脉高压和右心室增大。从出生后第4天开始暴露于IHA的动物，右心室重量随肺血压升高呈线性增加（r = 0.72）；成年大鼠中未发现显著相关性（r = 0.16）。年轻低氧大鼠中这两个变量之间的密切相关性可能是由于发育中的心脏能够通过心肌细胞肥大和增生来应对慢性低氧。
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