Ostádal B, Procházka J, Pelouch V, Urbanová D, Widimský J
Physiol Bohemoslov. 1984;33(2):129-38.
Intermittent high altitude hypoxia (8 hours a day, 5 days a week, stepwise up to the altitude of 7000 m, total number of exposures 24) induced in male and female rats, chronic pulmonary hypertension and right ventricular hypertrophy. No significant sex differences were found in both these parameters. A significant sex difference was demonstrated in the resistance of the cardiac muscle to acute anoxia in vitro: the myocardium of control female rats proved to be significantly more resistant to oxygen deficiency. Intermittent altitude hypoxia resulted in significantly enhanced resistance in both sexes, yet the sex difference was maintained. Sex differences were further observed in the growth response of experimental animals to the acclimatization process. Whereas the body weight of male rats exposed to intermittent altitude hypoxia was significantly lower, hypoxic females had body weights comparable to those of control animals.
对雄性和雌性大鼠进行间歇性高海拔低氧处理（每天8小时，每周5天，逐步升至7000米海拔，总暴露次数24次），可诱发慢性肺动脉高压和右心室肥大。在这两个参数上均未发现显著的性别差异。在体外心肌对急性缺氧的耐受性方面存在显著的性别差异：对照雌性大鼠的心肌对缺氧的耐受性明显更强。间歇性海拔低氧导致两性的耐受性均显著增强，但性别差异依然存在。在实验动物对适应过程的生长反应中还观察到了性别差异。暴露于间歇性海拔低氧的雄性大鼠体重显著降低，而低氧雌性大鼠的体重与对照动物相当。
