在韩国，柯萨奇病毒B感染与稽留流产高度相关。
Coxsackievirus B infection is highly related with missed abortion in Korea.
作者信息
Hwang Jung Hye, Kim Jeong Wook, Hwang Ji Young, Lee Kyung Min, Shim Hye Min, Bae Young Kyung, Paik Seung Sam, Park Hosun
机构信息
Department of Obstetrics and Gynecology, College of Medicine, Hanyang University, Seoul, Korea.
Department of Microbiology, College of Medicine, Yeungnam University, Daegu, Korea.
出版信息
Yonsei Med J. 2014 Nov;55(6):1562-7. doi: 10.3349/ymj.2014.55.6.1562.
PURPOSE
This study investigated the possible relationship between viral infection and first trimester pregnancy loss.
MATERIALS AND METHODS
A prospective study was performed on 51 gravidas with missed abortion, fetal anomaly, pre-term delivery, and full-tem delivery at Hanyang University Hospital. Enteroviruses were detected by semi-nested reverse transcription-polymerase chain reaction (RT-PCR) and immunohistochemistry in abortive tissues and placentas. Enterovirus serotypes were confirmed by genome sequencing. Herpesviruses were detected by PCR.
RESULTS
Coxsackievirus B3 (CVB3) was detected in 8 of 14 missed abortion cases, 1 of 27 full-term cases, and none of the 9 pre-term cases. Coxsackievirus B1 (CVB1) was detected in an encephalocele case. Herpes simplex virus type 1 was found in 4 full-term cases, 3 pre-term cases, and none of the missed abortion cases.
CONCLUSION
The prevalence of CVB3 was significantly higher in missed abortion cases compared to full-term or pre-term delivery cases. CVB infection may therefore be an important etiological agent of missed abortion.
目的
本研究调查病毒感染与孕早期流产之间的可能关系。
材料与方法
对汉阳大学医院51例发生稽留流产、胎儿畸形、早产和足月分娩的孕妇进行了一项前瞻性研究。通过半巢式逆转录聚合酶链反应（RT-PCR）和免疫组织化学方法在流产组织和胎盘中检测肠道病毒。通过基因组测序确认肠道病毒血清型。通过PCR检测疱疹病毒。
结果
在14例稽留流产病例中的8例、27例足月病例中的1例以及9例早产病例中均未检测到柯萨奇病毒B3（CVB3）。在1例脑膨出病例中检测到柯萨奇病毒B1（CVB1）。在4例足月病例、3例早产病例中发现了1型单纯疱疹病毒，而在稽留流产病例中均未发现。
结论
与足月或早产病例相比，稽留流产病例中CVB3的患病率显著更高。因此，CVB感染可能是稽留流产的重要病因。
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