Marmor A, Green T, Krakuer J, Szucs T, Schneeweiss A
Cardiology Department, Safed Medical Center, Israel.
Am J Med. 1989 Dec 26;87(6B):61S-63S. doi: 10.1016/0002-9343(89)90095-8.
We studied the effect of a single dose of cilazapril, 5.0 mg orally, on systolic and diastolic cardiac function in eight hypertensive patients using a double-blind crossover placebo-controlled design. All patients had concentric left ventricular hypertrophy (measured by echocardiography), unimpaired systolic function (measured by radionuclide ventriculography), and long-standing hypertension treated by a combination of beta-blockers and diuretics. Radionuclide scintigraphy was performed with cilazapril and placebo, given one week apart. A two-week washout period of all cardioactive drugs preceded the study. Within three hours after oral administration of cilazapril, the time to peak filling rate of the left ventricle, expressed as a percentage of diastole, was reduced from 44.5 +/- 13.2 percent to 31.2 +/- 7.2 percent (p less than 0.05). Systolic blood pressure was also significantly reduced by cilazapril. Heart rate was slightly reduced. Left ventricular ejection fraction, peak filling rate, and the absolute time to peak filling rate were not significantly altered. Cilazapril improves a sensitive index of diastolic cardiac function in hypertensive patients.
我们采用双盲交叉安慰剂对照设计，研究了口服单剂量5.0毫克西拉普利对8名高血压患者心脏收缩和舒张功能的影响。所有患者均有向心性左心室肥厚（通过超声心动图测量）、收缩功能未受损（通过放射性核素心室造影测量），且长期高血压通过β受体阻滞剂和利尿剂联合治疗。分别在服用西拉普利和安慰剂一周后进行放射性核素闪烁扫描。在研究前，所有心血管活性药物均有两周的洗脱期。口服西拉普利后三小时内，左心室峰值充盈率（以舒张期百分比表示）的时间从44.5±13.2%降至31.2±7.2%（p<0.05）。西拉普利还显著降低了收缩压。心率略有降低。左心室射血分数、峰值充盈率和达到峰值充盈率的绝对时间无显著变化。西拉普利改善了高血压患者舒张性心功能的一个敏感指标。
