Martinez-Pereira Malcon Andrei, Franceschi Raphaela da Cunha, Coelho Bárbara Paranhos, Fünkler Gustavo da Rosa, Zancan Denise Maria
Centro Ciências da Saúde, Universidade de Cruz Alta, Cruz Alta, Brazil. ; Laboratório de Neurobiologia Comparada, Departamento de Fisiologia, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
Laboratório de Neurobiologia Comparada, Departamento de Fisiologia, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil. ; Programa de Pós-Graduação em Neurociências, Instituto de Ciências Básicas da Saúde (ICBS), Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
Lab Anim Res. 2014 Sep;30(3):136-41. doi: 10.5625/lar.2014.30.3.136. Epub 2014 Sep 29.
Digestive disorders caused by sudden changes in diet or inappropriate diet are among the most common disorders of the digestive system. Cecal or intestinal tympany, one consequence of inappropriate diet, is characterized by the accumulation of gases, marked distension of the cecum and colon and the induction of inflammatory processes. To know the effects of intestinal tympany on the enteric plexuses, we developed a method of experimental tympanic colic (TC) in the Chinchilla lanigera. This species was used in view of its susceptibility to TC. TC was induced with a diet rich in alfalfa associated with grain overload for two weeks. Physical and clinical examination including the von Frey test confirmed the diagnosis. The chinchillas with acute abdomen were treated with 1% ketoprofen and resumption of a balanced diet. Necropsy and histopathological analysis showed tympany-induced alterations mainly in the cecum and colon. After treatment, the control conditions were restored. The TC protocol is proposed as an experimental approach designed to aid the study of the effects of acute intestinal inflammation and obstruction caused by an inappropriate diet.
由饮食突然改变或饮食不当引起的消化系统疾病是消化系统最常见的疾病之一。盲肠或肠道鼓胀是饮食不当的一个后果，其特征是气体积聚、盲肠和结肠明显扩张以及炎症过程的诱发。为了了解肠道鼓胀对肠神经丛的影响，我们在毛丝鼠中开发了一种实验性鼓胀性绞痛（TC）方法。鉴于其对TC的易感性，使用了该物种。通过富含苜蓿并伴有谷物过量的饮食诱导TC两周。包括冯·弗雷试验在内的体格和临床检查证实了诊断。对患有急腹症的毛丝鼠用1%酮洛芬治疗并恢复均衡饮食。尸检和组织病理学分析表明，鼓胀引起的改变主要发生在盲肠和结肠。治疗后，恢复了对照条件。提出TC方案作为一种实验方法，旨在帮助研究由不当饮食引起的急性肠道炎症和梗阻的影响。
