[热毒清对家兔线粒体H(+)-ATP合酶活性保护作用的实验研究]

[Experimental study of the protective action of re-du-qing on H(+)-APT synthase activity of mitochondria in the rabbit].

作者信息

Liang J Q, Huangfu Y M, Lu F E

出版信息

Zhong Xi Yi Jie He Za Zhi. 1989 Oct;9(10):607-8, 582.

Abstract

To observe the effect of Re-Du-Qing on the toxic effect of endotoxin, the rabbit model of general Shwartzman reaction was made by injection of endotoxin into ear vein and the H(+)-ATP synthase activities of rabbit liver mitochondria were measured. The results showed that the H(+)-ATP synthase activity of endotoxin group was significantly lower than that of the normal group and group which had been simultaneously injected Re-Du-Qing (P less than 0.05). The level of H(+)-ATP synthase activity was almost raised to normal value, when Re-Du-Qing or dexamethasone was injected simultaneously with endotoxin respectively. It suggested that Re-Du-Qing was able to alleviate the nocuous effect of endotoxin on H(+)-ATP synthase activity in the mitochondria of rabbit liver cells.

摘要

为观察热毒清对内毒素毒性作用的影响，采用耳静脉注射内毒素的方法制备家兔全身性施瓦茨曼反应模型，并测定家兔肝线粒体H(+)-ATP合酶活性。结果显示，内毒素组的H(+)-ATP合酶活性显著低于正常组和同时注射热毒清的组（P<0.05）。当分别与内毒素同时注射热毒清或地塞米松时，H(+)-ATP合酶活性水平几乎升高至正常值。提示热毒清能够减轻内毒素对家兔肝细胞线粒体H(+)-ATP合酶活性的有害作用。